|
Variables
|
Discovery study
|
Replication study
|
Combined study
|
|---|
|
Cases/controls
|
OR (95% CI)
|
P
|
Cases/controls
|
OR (95% CI)
|
P
|
Cases/controls
|
OR (95% CI)
|
P
|
|---|
|
AG
|
AA+GG
|
AG
|
AA+GG
|
AG
|
AA+GG
|
|---|
|
Age (ys)
|
|
≤55
|
10/0.6
|
123.2/128.8
|
8.57 (1.28–76.03)
|
0.010
|
13.2/1.7
|
231.5/198.5
|
5.11 (1.20–23.49)
|
0.026
|
23.2/2.3
|
354.7/327.3
|
9.62 (2.37–41.84)
|
1.18 × 10− 4
|
|
>55
|
16.2/1.6
|
344.6/309
|
6.39 (1.60–28.85)
|
0.007
|
33.4/3.8
|
651/684
|
7.88 (2.64–20.18)
|
8.23 × 10− 5
|
49.6/5.4
|
995.6/993
|
9.13 (3.36–22.70)
|
6.04 × 10− 8
|
|
Pi
| | | |
0.7
| | | |
3.17 × 10−3
| | | |
5.12 × 10−4
|
|
Gender
|
|
Females
|
6/0.2
|
70.2/139.6
|
2.81 (2.22–3.47)
|
0.008
|
13.6/1.8
|
231.4/268
|
7.35 (1.76–33.38)
|
0.008
|
19.6/2
|
301.6/407.6
|
12.43 (3.03–54.68)
|
6.36 × 10−5
|
|
Males
|
20.2/2
|
397.6/298.2
|
7.15 (1.55–29.07)
|
0.009
|
33/3.7
|
694/614.5
|
7.09 (2.38–17.14)
|
7.95 × 10−4
|
53.2/5.7
|
1091.6/912.7
|
7.35 (3.02–15.98)
|
8.61 × 10−7
|
|
Pi
| | | |
1.125
| | | |
0.099
| | | |
0.014
|
|
Drinking
|
|
Never
|
3/2.2
|
320.2/333.8
|
1.78 (0.30–11.79)
|
0.505
|
9.6/1.5
|
574.4/652
|
5.17 (1.19–22.93)
|
0.025
|
12.6/3.7
|
894.6/985.8
|
3.36 (1.11–9.83)
|
0.029
|
|
Ever+current
|
23.2/0
|
147.6/104
|
1.64 (1.47–1.75)
|
1.07 × 10–4
|
37/4
|
351/230.5
|
5.88 (2.03–16.01)
|
8.76 × 10−5
|
60.2/4
|
498.6/334.5
|
9.78 (3.56–24.83)
|
9.43 × 10−8
|
|
Pi
| | | |
2.12 × 10−4
| | | |
3.50 × 10−3
| | | |
3.25 × 10−6
|
- P, P value for haplotype model, which obtained in logistic regression with adjustment for age, sex, smoking status and drinking status
-
Pi, means P
2
/P
1
