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Table 4 Stratification analysis for associations between block 3 (rs12564469-rs9434711) haplotypes and HCC risk in the discovery, replication and combined studies

From: A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk

Variables Discovery study Replication study Combined study
Cases/controls OR (95% CI) P Cases/controls OR (95% CI) P Cases/controls OR (95% CI) P
AG AA+GG AG AA+GG AG AA+GG
Age (ys)
 ≤55 10/0.6 123.2/128.8 8.57 (1.28–76.03) 0.010 13.2/1.7 231.5/198.5 5.11 (1.20–23.49) 0.026 23.2/2.3 354.7/327.3 9.62 (2.37–41.84) 1.18 × 10− 4
 >55 16.2/1.6 344.6/309 6.39 (1.60–28.85) 0.007 33.4/3.8 651/684 7.88 (2.64–20.18) 8.23 × 10− 5 49.6/5.4 995.6/993 9.13 (3.36–22.70) 6.04 × 10− 8
Pi     0.7     3.17 × 10−3     5.12 × 10−4
Gender
 Females 6/0.2 70.2/139.6 2.81 (2.22–3.47) 0.008 13.6/1.8 231.4/268 7.35 (1.76–33.38) 0.008 19.6/2 301.6/407.6 12.43 (3.03–54.68) 6.36 × 10−5
 Males 20.2/2 397.6/298.2 7.15 (1.55–29.07) 0.009 33/3.7 694/614.5 7.09 (2.38–17.14) 7.95 × 10−4 53.2/5.7 1091.6/912.7 7.35 (3.02–15.98) 8.61 × 10−7
Pi     1.125     0.099     0.014
Drinking
 Never 3/2.2 320.2/333.8 1.78 (0.30–11.79) 0.505 9.6/1.5 574.4/652 5.17 (1.19–22.93) 0.025 12.6/3.7 894.6/985.8 3.36 (1.11–9.83) 0.029
 Ever+current 23.2/0 147.6/104 1.64 (1.47–1.75) 1.07 × 10–4 37/4 351/230.5 5.88 (2.03–16.01) 8.76 × 10−5 60.2/4 498.6/334.5 9.78 (3.56–24.83) 9.43 × 10−8
Pi     2.12 × 10−4     3.50 × 10−3     3.25 × 10−6
  1. P, P value for haplotype model, which obtained in logistic regression with adjustment for age, sex, smoking status and drinking status
  2. Pi, means P 2 /P 1