Table 4 Stratification analysis for associations between block 3 (rs12564469-rs9434711) haplotypes and HCC risk in the discovery, replication and combined studies
Variables | Discovery study | Replication study | Combined study | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cases/controls | OR (95% CI) | P | Cases/controls | OR (95% CI) | P | Cases/controls | OR (95% CI) | P | ||||
AG | AA+GG | AG | AA+GG | AG | AA+GG | |||||||
Age (ys) | ||||||||||||
≤55 | 10/0.6 | 123.2/128.8 | 8.57 (1.28–76.03) | 0.010 | 13.2/1.7 | 231.5/198.5 | 5.11 (1.20–23.49) | 0.026 | 23.2/2.3 | 354.7/327.3 | 9.62 (2.37–41.84) | 1.18 × 10− 4 |
>55 | 16.2/1.6 | 344.6/309 | 6.39 (1.60–28.85) | 0.007 | 33.4/3.8 | 651/684 | 7.88 (2.64–20.18) | 8.23 × 10− 5 | 49.6/5.4 | 995.6/993 | 9.13 (3.36–22.70) | 6.04 × 10− 8 |
Pi | 0.7 | 3.17 × 10−3 | 5.12 × 10−4 | |||||||||
Gender | ||||||||||||
Females | 6/0.2 | 70.2/139.6 | 2.81 (2.22–3.47) | 0.008 | 13.6/1.8 | 231.4/268 | 7.35 (1.76–33.38) | 0.008 | 19.6/2 | 301.6/407.6 | 12.43 (3.03–54.68) | 6.36 × 10−5 |
Males | 20.2/2 | 397.6/298.2 | 7.15 (1.55–29.07) | 0.009 | 33/3.7 | 694/614.5 | 7.09 (2.38–17.14) | 7.95 × 10−4 | 53.2/5.7 | 1091.6/912.7 | 7.35 (3.02–15.98) | 8.61 × 10−7 |
Pi | 1.125 | 0.099 | 0.014 | |||||||||
Drinking | ||||||||||||
Never | 3/2.2 | 320.2/333.8 | 1.78 (0.30–11.79) | 0.505 | 9.6/1.5 | 574.4/652 | 5.17 (1.19–22.93) | 0.025 | 12.6/3.7 | 894.6/985.8 | 3.36 (1.11–9.83) | 0.029 |
Ever+current | 23.2/0 | 147.6/104 | 1.64 (1.47–1.75) | 1.07 × 10–4 | 37/4 | 351/230.5 | 5.88 (2.03–16.01) | 8.76 × 10−5 | 60.2/4 | 498.6/334.5 | 9.78 (3.56–24.83) | 9.43 × 10−8 |
Pi | 2.12 × 10−4 | 3.50 × 10−3 | 3.25 × 10−6 | |||||||||