A rare CHD5 haplotype and its interactions with environmental factors predicting hepatocellular carcinoma risk

BMC Cancer

Table 3 rs12564469 and rs9434711 in replication and combined studies

	Alleles^a	Case, Control Ratio Counts^b	Case, Control Frequencies^c	Chi square	PAR^d	P _adjusted ^e	P _permutation ^f
Replication
rs12564469	A > G	659:289, 570:298	0.695, 0.657	3.065	0.0800	0.1029	0.1062
rs9434711	A > G	341:629, 309:579	0.352, 0.348	0.026	0.8718	0.8485	0.9601
Combined
rs12564469	A > G	1003:431, 857:445	0.699, 0.658	5.328	0.0210	0.0290	0.0286
rs9434711	A > G	511:953, 460:868	0.349, 0.346	0.022	0.8829	0.9137	0.9704

^aThe major allele is listed first, then the minor allele
^bNumber of alleles were compared in cases versus controls: allele(1):allele(2) cases, allele(1):allele(2) controls
^cFrequency of the association allele
^dPAR, population attributable risk
^eCalculated in logistical regression models with adjustment for age, gender, smoking and drinking status
^fP for 10⁵ permutation test

ISSN: 1471-2407