Table 2 Significant up or downregulated pathways of the hallmark MSigDB collection in PRA transgenic mammary glands, according to GSEA analysis with FDR < 25%
Pathways | NES | NOM p-val | FDR q-val | |
|---|---|---|---|---|
Upregulated | OXIDATIVE PHOSPHORYLATION | 1.90 | 0.00 | 0.003 |
ADIPOGENESIS | 1.40 | 0.01 | 0.139 | |
MITOTIC SPINDLE | 1.40 | 0.01 | 0.124 | |
GLYCOLYSIS | 1.30 | 0.05 | 0.219 | |
CHOLESTEROL HOMEOSTASIS | 1.30 | 0.12 | 0.224 | |
DNA REPAIR | 1.20 | 0.10 | 0.259 | |
MTORC1 SIGNALING | 1.20 | 0.08 | 0.234 | |
MYC TARGETS V2 | 1.20 | 0.17 | 0.231 | |
FATTY ACID METABOLISM | 1.20 | 0.15 | 0.221 | |
Downregulated | TNFA SIGNALING VIA NFKB | −2.20 | 0.00 | 0.000 |
IL6 JAK STAT3 SIGNALING | −2.00 | 0.00 | 0.001 | |
ALLOGRAFT REJECTION | −1.90 | 0.00 | 0.003 | |
INFLAMMATORY RESPONSE | −1.80 | 0.00 | 0.003 | |
TGF BETA SIGNALING | −1.70 | 0.00 | 0.005 | |
KRAS SIGNALING UP | −1.60 | 0.00 | 0.025 | |
APOPTOSIS | −1.60 | 0.00 | 0.025 | |
EPITHELIAL MESENCHYMAL TRANSITION | −1.60 | 0.00 | 0.023 | |
UV RESPONSE DN | −1.60 | 0.00 | 0.020 | |
HEDGEHOG SIGNALING | −1.60 | 0.04 | 0.025 | |
INTERFERON GAMMA RESPONSE | −1.50 | 0.01 | 0.034 | |
IL2 STAT5 SIGNALING | −1.40 | 0.02 | 0.100 | |
COMPLEMENT | −1.30 | 0.04 | 0.125 | |
KRAS SIGNALING DOWN | −1.30 | 0.07 | 0.212 | |
HYPOXIA | −1.30 | 0.06 | 0.205 | |
APICAL SURFACE | −1.30 | 0.18 | 0.214 | |
APICAL JUNCTION | −1.30 | 0.07 | 0.203 | |
PI3K AKT MTOR SIGNALING | −1.20 | 0.13 | 0.239 | |
G2M CHECKPOINT | −1.20 | 0.11 | 0.248 |