Skip to main content

Table 2 Significant up or downregulated pathways of the hallmark MSigDB collection in PRA transgenic mammary glands, according to GSEA analysis with FDR < 25%

From: Gene expression profile and cancer-associated pathways linked to progesterone receptor isoform a (PRA) predominance in transgenic mouse mammary glands

  Pathways NES NOM p-val FDR q-val
Upregulated OXIDATIVE PHOSPHORYLATION 1.90 0.00 0.003
ADIPOGENESIS 1.40 0.01 0.139
MITOTIC SPINDLE 1.40 0.01 0.124
GLYCOLYSIS 1.30 0.05 0.219
CHOLESTEROL HOMEOSTASIS 1.30 0.12 0.224
DNA REPAIR 1.20 0.10 0.259
MTORC1 SIGNALING 1.20 0.08 0.234
MYC TARGETS V2 1.20 0.17 0.231
FATTY ACID METABOLISM 1.20 0.15 0.221
Downregulated TNFA SIGNALING VIA NFKB −2.20 0.00 0.000
IL6 JAK STAT3 SIGNALING −2.00 0.00 0.001
ALLOGRAFT REJECTION −1.90 0.00 0.003
INFLAMMATORY RESPONSE −1.80 0.00 0.003
TGF BETA SIGNALING −1.70 0.00 0.005
KRAS SIGNALING UP −1.60 0.00 0.025
APOPTOSIS −1.60 0.00 0.025
EPITHELIAL MESENCHYMAL TRANSITION −1.60 0.00 0.023
UV RESPONSE DN −1.60 0.00 0.020
HEDGEHOG SIGNALING −1.60 0.04 0.025
INTERFERON GAMMA RESPONSE −1.50 0.01 0.034
IL2 STAT5 SIGNALING −1.40 0.02 0.100
COMPLEMENT −1.30 0.04 0.125
KRAS SIGNALING DOWN −1.30 0.07 0.212
HYPOXIA −1.30 0.06 0.205
APICAL SURFACE −1.30 0.18 0.214
APICAL JUNCTION −1.30 0.07 0.203
PI3K AKT MTOR SIGNALING −1.20 0.13 0.239
G2M CHECKPOINT −1.20 0.11 0.248
  1. NES normalized enrichment score, NOM p-val nominal p-value, FDR q-val false discovery rate q-value