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Fig. 3 | BMC Cancer

Fig. 3

From: Gene expression profiling of 1200 pancreatic ductal adenocarcinoma reveals novel subtypes

Fig. 3

Functional annotation of PDAC subtypes. a Heatmap showing six subtypes of PDAC in training dataset using the 160 subtype specific genes, which reveals distinct gene expression patterns between subtypes. b Heatmap also showing six subtypes of PDAC in merged validation dataset using the 160 subtype specific genes, with similar gene expression patterns (subtype specific genes are highly expressed in the corresponded subtype) as observed in the training dataset. c GSEA analysis reveals distinct enriched gene sets between subtypes. In the heatmap, rows are defined by the selected 60 gene sets, and columns by consensus scores for each subtype. Subtype enriched gene sets are highlighted by different color, L1 (light red), L2 (light brown), L3 (light blue), L4 (light orange), L5 (light purple) and L6 (light green). d-f Heatmaps showing six subtypes of PDAC in three independent validation datasets (GSE71729, Bailey and Collisson) using the 160 subtype specific genes, with similar gene expression patterns (subtype specific genes are highly expressed in the corresponded subtype) as observed in the training dataset

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