Table 5 Phamacokinetics results for imaging part (A) and therapeutic part (B)
Parameter | Cmax | Tmax | T1/2 | AUC C0-336a | CL | Vdss |
|---|---|---|---|---|---|---|
Units | ng/mL | Hours | Hours | ng*Hours/mL | mL/Hours | mL |
A. Imaging Part (n = 17) | ||||||
Mean | 483.8 | 1.3 | 265.7 | 154,724 | 38.6 | 3311.9 |
S.D. | 193.3 | 2.2 | 316.9 | 378,371 | 15.9 | 998.3 |
%CV | 39.9 | 167.9 | 119.3 | 244.55 | 41.3 | 30.3 |
B. Therapeutic part (n = 8) | ||||||
ARM A (370 MBq, n = 3) | ||||||
Mean | 365.4 | 0.00 | 87.4 | 42,106.7 | 255.4 | 4950.0 |
S.D. | 240.3 | 66.6 | 38,489.5 | 391.9 | 4811.6 | |
%CV | 65.7 | 76.2 | 91.41 | 153.5 | 97.2 | |
ARM B (1100 MBq, n = 4b) | ||||||
Mean | 362.0 | 1.0 | 61.8 | 38,275.0 | 63.0 | 1787.7 |
S.D. | 112.2 | 1.1 | 29.0 | 15,024.7 | 46.1 | 1040.5 |
%CV | 31.0 | 115.5 | 46.9 | 39.25 | 73.1 | 58.2 |