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Table 4 Association between HPV and LC3B status on overall and disease-free survival in oropharyngeal SCC (n = 47)

From: Differences in LC3B expression and prognostic implications in oropharyngeal and oral cavity squamous cell carcinoma patients

LC3B and HPV status Overall survival Disease-free survival
  HR* (95% CI) P value HR* (95% CI) P value
A. Joint-effects presentation
 HPV positive/Low LC3B (n = 18) 1.00   1.00  
 HPV positive/High LC3B (n = 11) 2.85 (0.77–10.47) 0.115 1.91 (0.36–10.22) 0.449
 HPV negative/Low LC3B (n = 8) 0.82 (0.24–2.82) 0.756 1.45 (0.30–7.15) 0.647
 HPV negative/High LC3B (n = 10) 4.76 (1.23–18.48) 0.024* 2.83 (0.57–0.57) 0.205
B. Stratified presentation
 HPV positive/Low LC3B (n = 18) 1.00   1.00  
 HPV positive/High LC3B (n = 11) 2.95 (0.66–13.25) 0.159 1.83 (0.28–11.79) 0.524
 HPV negative/Low LC3B (n = 8) 1.00   1.00  
 HPV negative/High LC3B (n = 10) 18.71 (1.3–270.24) 0.032* 3.35 (0.31–36.78) 0.323
  1. Clinical variables adjusted
  2. *= statistical significance (p < 0.05)