Haemophagocytic lymphohistiocytosis occurred during induction chemotherapy in an acute monocytic leukemia patient with FLT3-ITD and DNMT3A mutations

Table 1 The clinical parameters of the patient

Parameters	Before chemotherapy	d6 during the IA chemotherapy	d11–14 after finishing chemotherapy	d20 after finishing chemotherapy
WBC (×10⁹/L)	25.3	3.2	0.4	15.0
Hb (g/L)	142	66	73	78
PLT (×10⁹/L)	11.0	5	1	42
APTT (s)	57.7	72	104	46.2
PT (s)	14.0	14.6	30.5	11.8
Fbg (g/L)	3.1	2.2	0.87	4.8
TG (mmol/L)	1.5	–	0.8	0.9
SF (μg/L)	688	324	> 3000	1259
PCT (ng/mL)	2.8	0.75	3.8	0.7
CRP (mg/L)	44.5	25.4	35.7	49.1
LDH (U/L)	303	481	57	392

WBC white blood cell (normal range, 4-10 × 10⁹/L), Hb hemoglobin (normal range, 120–150 g/L), PLT platelet (normal range,100–300 × 10⁹/L), APTT activated partial prothrombin time (normal range, 21.1–36.5 s), P T prothrombin time (normal range, 9.8–12.1 s), Fbg fibrinogen (normal range, 1.8–3.5 g/L), TG triglycerides (normal range, 0–1.7 mmol/L), SF serum ferritin (normal range, 30–400 μg/L), PCT:procalcitonin (< 0.5 ng/mL), CRP C-reactive protein (normal range, 0–8 mg/L), LDH lactate dehydrogenase (normal range, 0–248 U/L), IA regimen idarubicin, 8 mg/m²/d at d1–3, Cytarabine, 100 mg/m²/d at d1–7

ISSN: 1471-2407