Table 1 Assessment of correlation between levels of siRNA-mediated LRP knockdown and viability, apoptotic levels and caspase-3 activity of early (SW-480) and late (DLD-1) stage colorectal cancer cells, using Pearson’s correlation co-efficients (R)
Cell line | SW-480 | DLD-1 |
|---|---|---|
Correlation between total LRP levels before and after siRPSA #1 transfection (R-value) | 0.91 | 0.96 |
Correlation between siRPSA #1-mediated LRP knockdown and reduction in cell viability (R-value) | 0.99 | 0.98 |
Correlation between siRPSA #2-mediated LRP knockdown and reduction in cell viability (R-value) | 0.99 | 0.93 |
Correlation between total levels of apoptosis and total LRP levels after siRPSA #1 transfection (R-value) | 0.99 | 0.98 |
Correlation between increases in caspase-3 activity and total LRP levels after siRPSA #1 (R-value) | 0.94 | 0.93 |