Table 2 Risk of SPC after BC diagnosis by follow-up, age, and period (1993–2013)

SIR

O/E

CI

SIR

SIR

SIR

SIR

SIR

SIR

SIR

SIR

SIR

All SPCs

0.94#

(3821/4086.59)

(0.91–0.97)

1.21#

0.89#

0.92#

0.86#

1.50#

1.04

0.90#

0.85#

0.99

All SPCs excluding BC, KC, pelvic and ureteral cancer

0.96#

(3751/3921.87)

(0.93–0.99)

1.20#

0.91#

0.95

0.90#

1.36

1.06

0.92#

0.87#

1.01

Buccal cavity, pharynx

0.79

(53/67.09)

(0.59–1.03)

0.23#

1.09

0.62

0.76

0

1.03

0.71#

0.68

0.87

Tongue

0.37#

(4/10.95)

(0.10–0.94)

0

0.43

0.32

0.57

0

0.67

0.26#

0.22

0.47

Salivary gland

0.92

(6/6.51)

(0.34–2.01)

0

1.10

1.58

0

0

1.17

0.85

0.76

1.03

Tonsil

0.27#

(2/7.32)

(0.03–0.99)

0

0.66

0

0

0

0.40

0.21

0

0.44

Hypopharynx

1.19

(19/15.94)

(0.72–1.86)

0.49

1.33

0.86

2.01

0

1.69

1.05

1.48

0.98

Digestive system

0.85#

(1833/2160.13)

(0.81–0.89)

0.81#

0.79#

0.96

0.82#

1.41

0.95

0.81#

0.79#

0.89#

Esophagus

0.97

(94/97.04)

(0.78–1.19)

0.96

0.96

1.07

0.80

0

1.05

0.95

0.83

1.08

Stomach

0.79#

(632/796.08)

(0.73–0.86)

0.73#

0.73#

0.87#

0.87

1.47

0.92

0.75#

0.73#

0.84#

Small intestine

1.43

(20/14.02)

(0.87–2.20)

2.31

1.55

1.22

0.84

0

1.33

1.47

2.13#

0.95

Colon

0.84#

(271/321.74)

(0.74–0.95)

0.95

0.87

0.86

0.70#

1.72

0.90

0.82#

0.77#

0.88

Rectum, rectosigmoid junction

0.91

(233/255.77)

(0.80–1.04)

1.15

0.75#

1.02

0.95

1.59

0.88

0.91

0.82

0.96

Anus, anal canal

0.97

(5/5.15)

(0.32–2.27)

1.51

0.46

1.34

1.20

0

2.12

0.72

0.89

1.03

Liver

0.79#

(240/304.17)

(0.69–0.90)

0.63#

0.74#

0.94

0.79

1.09

0.95

0.71#

0.77#

0.80#

Gallbladder

0.77

(43/55.52)

(0.56–1.04)

1.18

0.57#

0.86

0.83

0

0.92

0.75

0.71

0.82

Bile ducts, other biliary

0.92

(166/180.66)

(0.78–1.07)

0.55#

0.92

1.18

0.73

2.04

0.95

0.91

0.92

0.92

Pancreas

0.98

(122/124.96)

(0.81–1.17)

0.67

0.98

1.19

0.82

2.2

1.27

0.90

0.81

1.08

Respiratory system

1.05

(848/807.86)

(0.98–1.12)

1.06

1.07

1.01

1.05

0

1.27#

1.01

0.93

1.13#

Nose, nasal cavity, ear

1.07

(8/7.51)

(0.46–2.10)

2.06

1.57

0.46

0

0

0

1.41

0.62

1.39

Larynx

1.20

(58/48.45)

(0.91–1.55)

2.18#

1.09

0.87

1.26

0

1.18

1.21

1.1

1.27

Lung, bronchus

1.05

(782/748.26)

(0.97–1.12)

0.98

1.07

1.03

1.06

0

1.30#

1

0.93

1.13#

Female breast

1.12

(34/30.38)

(0.78–1.56)

1.35

0.72

1.11

1.91

0.90

1.19

1.09

1.70#

0.78

Female genital system

1.10

(33/29.98)

(0.76–1.55)

1.71

1.16

0.59

1.33

2.75

0.97

1.07

1.27

0.96

Male genital system

1.45#

(513/353.32)

(1.33–1.58)

4.04#

1.30#

1.04

0.95

5.18

1.66#

1.41#

1.30#

1.53#

Prostate

1.46#

(505/346.97)

(1.33–1.59)

4.08#

1.31#

1.03

0.95

7.54

1.66#

1.41#

1.32#

1.53#

Testis

3.95

(3/0.76)

(0.82–11.55)

0

6.05

4.61

0

0

4.17

4.76

0

6.83#

Urinary system

0.73#

(170/232.70)

(0.62–0.85)

2.03#

0.72#

0.42#

0.37#

6.63#

0.89

0.65#

0.61#

0.81#

Urinary bladder

0.45#

(63/139.70)

(0.35–0.58)

1.63#

0.49#

0.12#

0.08#

12.41#

0.46#

0.41#

0.33#

0.54#

Kidney parenchyma

1.47#

(100/67.98)

(1.20–1.79)

3.23#

1.44#

1.04

1.08

4.54#

1.40

1.44#

1.32

1.56#

Renal pelvis, other urinary

0.28#

(7/25.02)

(0.11–0.58)

1.03

0.10#

0.40

0.00#

0

0.90

0.15#

0.43

0.19#

Brain, central nervous system

0.76

(16/21.09)

(0.43–1.23)

0.38

0.91

0.97

0.28

0

0.56

0.85

0.72

0.79

Thyroid

1.21

(107/88.29)

(0.99–1.46)

2.24#

1.29

0.97

0.83

1.08

1.35#

1.09

1.04

1.28#

Lymphatic, hematopoietic

0.75#

(98/130.52)

(0.61–0.92)

1.08

0.64#

0.73

0.83

0.63

0.57#

0.81

0.69#

0.79

Hodgkin lymphoma

0.77

(2/2.58)

(0.09–2.80)

3.11

0.92

0

0

0

0

1.15

0.99

0.64

Non-Hodgkin lymphoma

0.69#

(47/68.39)

(0.50–0.91)

1.21

0.75

0.35#

0.75

1.17

0.43#

0.76

0.64

0.71

Myeloma

0.82

(19/23.27)

(0.49–1.28)

1.09

0.64

0.87

0.95

0

0.79

0.83

0.70

0.89

Leukemia

0.82

(32/38.93)

(0.56–1.16)

0.84

0.44#

1.31

0.90

0

0.68

0.88

0.78

0.85