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Fig. 2 | BMC Cancer

Fig. 2

From: Apatinib treatment for KIT- and KDR-amplified angiosarcoma: a case report

Fig. 2

Genomic profiling identifies amplification of KDR (VEGFR2) and KIT4. Genomic profiling by a hybrid capture-based next-generation sequencing assay was performed on the resected specimen tissue to a coverage depth of 561×, revealing 4 distinct genomic alterations, including KIT amplification (8 copies) and KDR amplification (8 copies)(blue arrow, KDR and KIT are relatively close to the genome, so they can’t be separated.). Copy number was determined by modeling copy variation and aneuploidy across the genome, and was compared with process-matched normal controls

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