Hepatic arterial infusion chemotherapy followed by sorafenib in patients with advanced hepatocellular carcinoma (HICS 55): an open label, non-comparative, phase II trial

Table 3 Univariate and multivariate analyses of factors associated with response

Parameters	Univariate analysis	Multivariate analysis
Parameters	P value	Odds ratio	95% CI	P value
Age (< 65/≥ 65 years)	0.462
Gender (Male/Female)	0.917
ECOG performance status (0/1)	0.667
Platelet count (< 14.9 × 10⁴/> 14.9 × 10⁴ /μL)	0.487
Child-Pugh score (A/B)	0.736
Diameter of main tumor (< 80 mm/≥ 80 mm)	0.52
Macroscopic vascular invasion (without/with)	0.018
TACE refractory (without/with)	0.007	5.689	1.490–21.724	0.011
AFP (< 1895/≥ 1895 ng /mL)	0.149
DCP (< 3854/≥ 3854 mAU/mL)	0.547
Extrahepatic spread (without/with)	0.3

Abbreviations: AFP alpha-fetoprotein, DCP des-gamma-carboxy prothrombin, ECOG Eastern Cooperative Oncology Group, MVI macroscopic vascular invasion, TACE transarterial chemoembolization

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