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Table 3 Univariate and multivariate analyses of factors associated with response

From: Hepatic arterial infusion chemotherapy followed by sorafenib in patients with advanced hepatocellular carcinoma (HICS 55): an open label, non-comparative, phase II trial

Parameters Univariate analysis Multivariate analysis
P value Odds ratio 95% CI P value
Age (<  65/≥ 65 years) 0.462    
Gender (Male/Female) 0.917    
ECOG performance status (0/1) 0.667    
Platelet count (<  14.9 × 104/>  14.9 × 104 /μL) 0.487    
Child-Pugh score (A/B) 0.736    
Diameter of main tumor (<  80 mm/≥ 80 mm) 0.52    
Macroscopic vascular invasion (without/with) 0.018    
TACE refractory (without/with) 0.007 5.689 1.490–21.724 0.011
AFP (<  1895/≥ 1895 ng /mL) 0.149    
DCP (<  3854/≥ 3854 mAU/mL) 0.547    
Extrahepatic spread (without/with) 0.3    
  1. Abbreviations: AFP alpha-fetoprotein, DCP des-gamma-carboxy prothrombin, ECOG Eastern Cooperative Oncology Group, MVI macroscopic vascular invasion, TACE transarterial chemoembolization