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Fig. 1 | BMC Cancer

Fig. 1

From: ARL2 overexpression inhibits glioma proliferation and tumorigenicity via down-regulating AXL

Fig. 1

Decreased ARL2 expression is clinically relevant with poor prognosis of glioma patients. a qRT-PCR analyses of ARL2 mRNA in WHO grade II-IV glioma and non-tumor samples (grade II, n = 3; grade III, n = 3; grade IV, n = 3, non-tumor n = 3) (non-tumor vs. grade II, P = 0.0489; non-tumor vs. grade III, P = 0.0075; non-tumor vs. grade IV, P = 0.0046; one-way ANOVA). b Western blot analyses of ARL2 protein in WHO grade II-IV glioma and non-tumor samples (grade II, n = 3; grade III, n = 3; grade IV, n = 3, non-tumor n = 3) (non-tumor vs. grade II, P = 0.0761; non-tumor vs. grade III, P = 0.0512; non-tumor vs. grade IV, P = 0.0033; one-way ANOVA). c Representative immunohistochemistry images and analyses of ARL2 protein in WHO grade II-IV glioma and non-tumor brain samples (grade II, n = 3; grade III, n = 9; grade IV, n = 8; non-tumor n = 3). Scale bar, 50 μm. (non-tumor vs. grade II, P = 0.0074; non-tumor vs. grade III, P < 0.0001; non-tumor vs. grade IV, P < 0.0001; one-way ANOVA). d Data from CGGA showed ARL2 mRNA expression decreased in grade IV compared to grade II (grade II, n = 33; grade III, n = 21; grade IV, n = 106) (grade II vs. grade IV, P < 0.0001; grade II vs. grade III, P = 0.8438, one way ANOVA). e, f Data from Rembrandt database (e, non-tumor, n = 28; astrocytoma, n = 148; oligodendroglioma, n = 67; GBM, n = 228) (non-tumor vs. Astrocytoma, P = 0.0007; non-tumor vs. oligodendroglioma, P < 0.0001; non-tumor vs. GBM, P < 0.0001; one-way ANOVA) and TCGA (F, normal, n = 11; classical, n = 54; mesenchymal, n = 58; neural, n = 33; proneural, n = 57) (normal vs. classical, P < 0.0001; normal vs. mesenchymal, P < 0.0001; normal vs. neural, P = 0.0188; normal vs. proneual,P < 0.0001 one-way ANOVA) revealed that ARL2 mRNA expression decreased in glioblastoma, compared with non-tumor brain tissues. g-i Data from CGGA (G, P = 0.0003, low, n = 148; high, n = 147), Rembrandt database (h, low, n = 171; high, n = 158) and TCGA (i, low, n = 287; high, n = 238) indicated ARL2 was opposite relevant to the poor prognosis of glioma patients

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