Identification of genes inducing resistance to ionizing radiation in human rectal cancer cell lines: re-sensitization of radio-resistant rectal cancer cells through down regulating NDRG1

Kim, Soon-Chan; Shin, Young-Kyoung; Kim, Ye-Ah; Jang, Sang-Geun; Ku, Ja-Lok

doi:10.1186/s12885-018-4514-3

Table 1 Gene ontology analysis of altered genes in radio-resistant rectal cancer cell lines

From: Identification of genes inducing resistance to ionizing radiation in human rectal cancer cell lines: re-sensitization of radio-resistant rectal cancer cells through down regulating NDRG1

Probe Set ID	Gene symbol	GO_BP			SNU-61		FC	SNU-283		FC	SNU-503		FC
Probe Set ID	Gene symbol	GO_BP			P	R	FC	P	R	FC	P	R	FC
7912157	ERRFI1				288	1288	4.5	52	206	4.0	334	1215	3.6
7938390	ADM	●	◎		178	746	4.2	185	524	2.8	222	469	2.1
7945680	H19				79	1562	19.8	65	265	4.1	74	6924	93.8
7952036	MPZL3				100	509	5.1	86	297	3.5	75	324	4.3
7954090	EMP1				654	1493	2.3	66	1171	17.8	811	3459	4.3
7978544	EGLN3	●	◎	◑	114	304	2.7	117	376	3.2	93	515	5.6
8004360	KCTD11				44	95	2.1	37	78	2.1	82	196	2.4
8020762	DSG3	◯			53	450	8.5	29	98	3.4	800	1741	2.2
8022711	DSC2	◯			589	1463	2.5	481	1017	2.1	561	1651	2.9
8026490	UCA1				485	1434	3.0	38	121	3.1	37	1153	31.3
8027002	GDF15				318	1203	3.8	332	843	2.5	73	255	3.5
8037374	PLAUR				109	228	2.1	59	152	2.6	49	115	2.4
8041508	QPCT				90	197	2.2	26	58	2.2	10	48	4.8
8051322	XDH	◑	◐		40	101	2.5	44	142	3.2	51	105	2.1
8077441	BHLHE40				240	904	3.8	193	470	2.4	178	476	2.7
8113214	GLRX	◑			32	90	2.8	116	459	4.0	31	133	4.3
8119161	PIM1				128	608	4.7	238	637	2.7	265	851	3.2
8123598	SERPINB1				443	1015	2.3	856	1918	2.2	81	271	3.3
8141328	CYP3A5	◑			350	785	2.2	283	998	3.5	16	46	3.0
8145454	BNIP3L				158	811	5.1	269	551	2.0	403	944	2.3
8150881	PLAG1				29	136	4.6	18	37	2.0	76	165	2.2
8153002	NDRG1				208	3499	16.8	463	1615	3.5	436	2010	4.6
8012953	TRIM16	◐			159	337	2.1	86	263	3.0	384	866	2.3
8054377	FHL2				165	505	3.1	157	451	2.9	49	124	2.5
8119898	VEGFA	●	◎		168	550	3.3	210	538	2.6	396	794	2.0
7969438	LMO7	●			273	666	2.4	179	557	3.1	48	320	6.6
7927915	STOX1				29	14	−2.1	47	17	−2.8	108	18	−5.9
7979281	WDHD1				288	114	−2.5	109	54	−2.0	238	96	−2.5
7996211	GINS3				115	41	−2.8	88	38	−2.3	159	58	−2.8
8017210	AP1S2				43	15	−2.9	82	32	−2.6	134	45	−3.0
8060813	MCM8				259	122	−2.1	340	170	−2.0	526	165	−3.2
8083656	MFSD1				665	301	−2.2	1212	530	−2.3	865	354	−2.4
8155327	ALDH1B1	◑			214	81	−2.6	1622	566	−2.9	299	133	−2.3

Genes that differently expressed more than 2-folds in radio-resistant rectal cancer cell lines were analyzed with gene ontology. (P: Parental rectal cancer cell line, R: Radio-resistant rectal cancer cell line, FC: Fold change, ●: Response to hypoxia, ◎: Response to oxygen levels, ◑: Oxidation reduction, ◐: Regulation of epithelial cell differentiation, and ◯: Cell-cell adhesion)

Back to article page

ISSN: 1471-2407

Contact us

Submission enquiries: bmccancer@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Cancer

Contact us