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Table 2 SBRT dose constraints. (TD = Target dose)

From: PROstate Multicentre External beam radioTHErapy Using a Stereotactic boost: the PROMETHEUS study protocol

Constraint

Per-Protocol

Minor Variation

Major Variation

CTVsbrt D98a

> 100% TD

95–100% TD

< 95% TD

PTVsbrt D50a

< 105% TD

105–110% TD

> 110% TD

PTVsbrt D90a

> 100% TD

95–100% TD

< 95% TD

PTVsbrt D95a

> 95% TD

90–95% TD

< 90% TD

PTVsbrt D99a

> 16 Gy

15–16 Gy

< 15 Gy

PTVsbrt Dmax to 0.1cc

< 110% TD

110–120% TD

> 120% TD

PTVsbrt Dmax

Not within a critical structure

Rectal Wall Dmax to 0.1cc

< 17 Gy

17–17.5 Gy

> 17.5 Gy

Rectal Wall V16 Gy

< 0.5cc

0.5-1cc

> 1cc

Rectal Wall V14 Gy

< 3cc

3-5 cc

> 5cc

Rectal Wall V12 Gy

< 30%

30–40%

> 40%

Rectal Wall V10 Gy

< 40%

40–50%

> 50%

Rectal Wall V8 Gy

< 60%

60–70%

> 70%

Rectal Mucosa Dmax to 0.1cc

< 15 Gy

15–15.5 Gy

> 15.5 Gy

Rectal Mucosa V14 Gy

< 0.5cc

0.5-1cc

> 1cc

Rectum Posterior Wall

< 8.5 Gy

8.5–9.5 Gy

> 9.5 Gy

Bladder Dmax to 0.1cc

< 110% TD

110–120% TD

> 120% TD

Bladder V19 Gy

< 10cc

10-15cc

> 15cc

Bladder V17 Gy

< 15%

15–20%

> 20%

Bladder V9 Gy

< 50%

50–60%

> 60%

Urethra PRV Dmax to 0.1cc

< 110% TD

110–115% TD

> 115% TD

Urethra PRV V105% TD

< 5%

5–15%

> 15%

Neck of Femurs Dmax to 0.1cc

< 8 Gy

8–9 Gy

9 Gy

Penile Bulb Dmax to 0.1cc (Recommended)

100% TD

100–105% TD

> 105% TD

Penile Bulb V10 Gy (Recommended)

<3cc

3-5cc

> 5cc

Intermediate Dose Spillage: ratio of volumes receiving 50% TD to 100% TD

< 4

4–5

> 5

Total Monitor Units

< 3× Dose in cGy

3–3.5× Dose in cGy

> 3.5× Dose in cGy

High Dose Conformation: Volume receiving 100% of TD divided by volume of PTVsbrt

< 1.1

1.1–1.2

> 1.2

  1. aWhere Urethra has been limited to 19 Gy, these volumes may exclude the urethra: eg. CTVsbrt D98 = CTVsbrt – Urethra PRV D98