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Table 3 Results of univariate and multivariate analyses of clinicopathological factors affecting the overall survival rate following surgery

From: High expression of forkhead box protein C2 is associated with aggressive phenotypes and poor prognosis in clinical hepatocellular carcinoma

Clinicopathologic variable Univariate analysis Multivariate analysis
RR 95%CI P value RR 95%CI P value
FOXC2 expression (low/high) 2.14 1.05–4.34 0.035a 2.21 1.06–4.57 0.033a
Age (≤65/> 65) 1.17 0.518–2.66 0.70
Gender (male/female) 1.13 0.485–2.62 0.78
Liver cirrhosis (negative/positive) 1.86 0.913–3.77 0.087
Differentiation (well or moderate/poor) 1.30 0.307–5.49 0.72
Pattern of tumor growth (Eg/Ig) 3.29 1.53–7.07 0.0023a 3.06 1.37–6.80 0.0062a
T classification (T1–3/T4) 4.33 1.82–10.34 < 0.001a 3.82 1.18–12.37 0.025a
Portal vein invasion (negative/positive) 2.19 1.03–4.65 0.042a 1.31 0.477–3.59 0.6
AFP level (normal/high) 1.24 0.529–2.91 0.62
PIVKA II level (normal/high) 0.749 0.323–1.73 0.50
  1. RR relative risk, CI confidence interval
  2. aStatistical significance is indicated by P < 0.05