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Fig. 2 | BMC Cancer

Fig. 2

From: Aggregation of lipid rafts activates c-met and c-Src in non-small cell lung cancer cells

Fig. 2

MβCD suppressed proliferation of A549 and H1993 cells whether followed by X-ray irradiation or not. Cells were pretreated with either control (DMEM) or MβCD (5 or 10 mM) for 1 h followed by X-ray irradiation to a discontinuous rising dose of 0, 4, 8 and 12 Gy. Then, cells were incubated for 30 days to allow macroscopic colony formation. The results showed that exposing A549 and H1993 cells to a rising dose of radiation either pretreated with DMEM or 5 or 10 mM MβCD inhibited cell proliferation in a radiation dose-dependent manner (a1 represents PE(%) of A549 cells under different conditions. b1-d1 represents PE(%) of A549 cells pretreated with the same concentration of MβCD (0, 5 or 10 mM, respectively) followed by different doses of X-ray(0, 4, 8 and 12 Gy). e1-h1 represents PE(%) of A549 cells pretreated with different concentration of MβCD (0, 5 or 10 mM) followed by the same doses of X-ray(0, 4, 8 and 12 Gy, respectively). a2 represents PE(%) of H1993 cells under different conditions. b2-d2 represents PE(%) of H1993 cells pretreated with the same concentration of MβCD (0, 5 or 10 mM, respectively) followed by different doses of X-ray(0, 4, 8 and 12 Gy). e2-h2 represents PE(%) of H1993 cells pretreated with different concentration of MβCD (0, 5 or 10 mM) followed by the same doses of X-ray(0, 4, 8 and 12 Gy, respectively). “no statistical significance” is shown as “ns”, “P < 0.05” is shown as “*”, “P < 0.01” is shown as “**”, and “P < 0.001” is shown as “***”)

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