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Fig. 11 | BMC Cancer

Fig. 11

From: Involvement of the CB2 cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212–2 in renal cell carcinoma

Fig. 11

Schematic model of the apoptotic effect of WIN-55 on RCC cells. a WIN-55 binds to CB1 receptor in the presence of CB2 receptor antagonist (AM-630) have no effect on proliferation. b WIN-55 binds to the CB2 receptor in the presence of CB1 receptor antagonist (SR141716A) and induces G0/G1 arrest, which further leads to anti-proliferation and apoptotic cell death

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BMC Cancer

ISSN: 1471-2407

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