Fig. 2

Comparative genomics TFBS analysis of the CA8 and CA11 promoters. Alignments of 17 and 24 mammal sequences corresponding to the promoters of full-length human CA8 transcript ENST00000317995 (a) and CA11 transcript ENST00000084798 (b), respectively, were analyzed for putative transcription factor binding sites by comparative genomics. For each, the 10 best scoring transcription factors were included in the figure, where height indicates the number of species supporting that prediction. Positive y-axis results indicate a TFBS predicted on the positive strand while negative y-axis indicates the negative strand. Conservation of sequence in the alignment, CpG ratio in the human sequence, and location of FANTOM CAGE peaks in the human sequence are included as subpanels. Location relative to TSS is marked across the bottom of the figure, and is relevant for all panels