Table 2 Multivariate analysis of prognostic factors for disease-specific survival of osteosarcoma patients according to age group
≤40 | 41–64 | ≥65 | |||||||
|---|---|---|---|---|---|---|---|---|---|
No. of patients | Hazard ratio (CI) | p value | No. of patients | Hazard ratio (CI) | p value | No. of patients | Hazard ratio (CI) | p value | |
Total | 760 | 173 | 110 | ||||||
Sex | |||||||||
Male | 426 | Reference | 93 | Reference | 53 | Reference | |||
Female | 334 | 0.93 (0.65–1.32) | 0.684 | 80 | 0.75 (0.42–1.33) | 0.318 | 57 | 1.06 (0.63–1.78) | 0.821 |
Metastasis at diagnosis | |||||||||
No | 646 | Reference | 139 | Reference | 80 | Reference | |||
Yes | 111 | 3.42 (2.27–5.15) | < 0.001 | 34 | 3.04 (1.63–5.69) | < 0.001 | 30 | 3.04 (1.63–5.69) | < 0.001 |
Tumor location | |||||||||
Extremity | 704 | Reference | 115 | Reference | 60 | Reference | |||
Trunk | 56 | 1.47 (0.83–2.60) | 0.185 | 58 | 1.64 (0.80–3.36) | 0.179 | 50 | 1.01 (0.53–1.93) | 0.969 |
Tumor size | |||||||||
≤ 8 cm | 296 | Reference | 70 | Reference | 36 | Reference | |||
> 8 cm and ≤ 16 cm | 373 | 1.72 (1.13–2.61) | 0.011 | 82 | 0.91 (0.50–1.68) | 0.770 | 62 | 1.03 (0.58–1.82) | 0.927 |
> 16 cm | 65 | 2.11 (1.13–3.93) | 0.019 | 15 | 1.50 (0.56–3.96) | 0.429 | 9 | 2.84 (1.16–6.97) | 0.023 |
Definitive surgery | |||||||||
Yes | 45 | Reference | 35 | Reference | 68 | Reference | |||
No | 715 | 3.74 (2.03–5.96) | < 0.001 | 138 | 1.01 (0.45–2.29) | 0.982 | 42 | 1.74 (0.86–3.45) | 0.124 |