The outcomes and prognostic factors in patients with osteosarcoma according to age: a Japanese nationwide study with focusing on the age differences

Table 1 Clinical and treatment characteristics for the patients overall according to age group

		Overall		≤40		41–64		≥65		p value
		No. of patients	%	No. of patients	%	No. of patients	%	No. of patients	%
Total		1043		760	70.1	173	17.5	110	12.4
Sex
Male		572	54.8	426	56.1	93	53.8	53	48.2	0.286
Female		471	45.2	334	43.9	80	46.2	57	51.8
Age (years), mean [range]				18 [4–40]		53 [41–64]		73 [65–91]
Tumor size (cm), mean [range]				10.1 [2.0–34.0]		10.1 [2.5–33.0]		10.2 [0.8–25.0]		0.961
≤ 8 cm		402	38.5	296	38.9	70	40.5	36	32.7	0.664
> 8 cm and ≤ 16 cm		517	49.6	373	49.1	82	47.4	62	56.4
> 16 cm		89	8.5	65	8.6	15	8.7	9	8.2
Unknown		35	3.4	26	3.4	6	3.4	3	2.7
Tumor location
Femur		516	49.4	394	51.8	74	42.8	48	43.6	< 0.001
Tibia		204	19.6	180	23.7	18	10.4	6	5.5
Fibula		27	2.6	23	3.0	3	1.7	1	0.9
Humerus		80	7.7	65	8.6	13	7.5	2	1.8
Distal extremity		52	5.0	42	5.5	7	4.1	3	2.7
Trunk		164	15.7	56	7.4	58	33.5	50	45.5
Metastasis at diagnosis
Yes		174	16.7	111	14.6	34	19.7	29	26.4	< 0.001
No		865	82.9	646	85.0	139	80.3	80	72.7
Unknown		4	0.4	3	0.4	0	0	1	0.9
Definitive surgery	Yes	921	88.3	715	94.1	138	79.8	68	61.8	< 0.001
Chemotherapy	Yes	954	91.5	746	98.2	153	88.4	55	50.0	< 0.001
	Setting of chemotherapy
	Adjuvant	832	79.8	674	88.7	125	72.3	33	30.0	< 0.001
	Palliative	110	10.5	62	8.2	27	15.6	21	19.1
	Unknown	12	1.2	10	1.3	1	0.6	1	0.9
	Chemotherapeutic agent
	ADR	876	84.0	695	91.4	141	81.5	40	36.4	< 0.001
	IFO	681	65.3	542	71.3	112	64.7	27	24.5	< 0.001
	CDDP	840	80.5	691	90.9	124	71.7	25	22.7	< 0.001
	MTX	654	62.7	598	78.7	51	29.5	5	4.5	< 0.001
Radiotherapy	Yes	163	15.6	72	9.5	47	27.2	44	40.0	< 0.001
	Setting of radiotherapy
	Adjuvant	32	19.6	16	22.2	9	19.1	7	15.9	0.098
	Palliative	55	33.7	19	26.4	13	27.7	23	52.3
	Definitive	70	42.9	34	47.2	24	51.1	12	27.3
	Unknown	6	3.7	3	4.2	1	2.1	2	4.5

ISSN: 1471-2407