Risk factors for esophageal fistula in thoracic esophageal squamous cell carcinoma invading adjacent organs treated with definitive chemoradiotherapy: a monocentric case-control study

Table 2 Univariate analysis for the incidence of esophageal fistula

Characteristics	EF+ (N = 28)	EF− (N = 88)	OR	95% CI	P-value
Age ≥ 65 years	13	47	0.76	0.32–1.77	0.520
Sex, male	23	79	0.52	0.16–1.72	0.286
ECOG PS 0/1	19/9	58/30	0.92	0.37–2.27	0.849
Tumor size ≥70 mm^a	19	47	2.07	0.82–5.23	0.123
Total circumferential lesion	20	40	3.00	1.19–7.54	0.019
Esophageal stenosis	18	56	1.03	0.42–2.50	0.950
Aorta invasion	16	38	1.75	0.74–4.14	0.200
Tracheal or bronchial invasion	24	68	1.76	0.55–5.69	0.341
WBC ≥ 10,000/μL	7	8	3.33	1.08–10.2	0.036
Hb < 12 g/dL	9	10	3.69	1.32–10.4	0.013
Alb < 3.5 g/dL	4	3	4.72	0.99–22.6	0.052
CRP ≥ 1.00 mg/dL^b	19	29	4.15	1.67–10.3	0.002

Abbreviations: EF esophageal fistula, OR odds ratio, CI confidence interval, WBC white blood cell, Hb hemoglobin, Alb albumin, CRP C reactive protein
^aData missing for one patient
^bData missing for two patients

ISSN: 1471-2407