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Table 3 Univariate and multivariate analyses by chi square and logistic regression, respectively, of grade 3 or 4 neutropenia and thrombocytopenia of the six final candidate SNPs with clinical parameters in the NSCLC cohort

From: Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy

 

Factors/Genotype

Number/ Percentage of grade 3/4 neutropenia (all cycles)

Grade 3/4 neutropenia

Number/Percentage of grade 3/4 thrombocytopenia (all cycles)

Grade 3/4 thrombocytopenia

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

OR (95%CI)

P value

OR (95%CI)

P value (adjusted)

OR (95%CI)

P value

OR (95%CI)

P value (adjusted)

Gender

Male

66

2.74 (0.83-9.04)

0.097

–

–

66

4.78 (1.46-15.7)

0.01

4.44 (1.27-15.6)

0.020

Female

22

22

Age

< 62

42

1.03 (0.42-2.51)

0.942

–

–

42

0.56 (0.24-1.31)

0.178

–

–

≥62

46

46

Stage

3

19

2.21 (0.78-6.24)

0.136

–

–

19

2.84 (0.99-9.12)

0.052

–

–

4

69

69

ECOG

0

27

0.80 (0.30-2.14)

0.659

–

–

27

0.87 (0.35-2.17)

0.758

–

–

1

61

61

ABCG2 Q141K

CC

59.60%

2.10 (0.84-5.28)

0.113

–

–

44.70%

2.99 (1.23-7.25)

0.015

3.79 (1.42-10.1)

0.008

CA/AA

75.60%

70.70%

SLC29A3 S158F

CC

50.00%

2.67 (0.99-7.22)

0.054

–

–

45.60%

1.85 (0.70-4.89)

0.109

–

–

CT/TT

72.70%

60.60%

NT5C2 D549E*

CC

57.10%

1.76 (0.64-4.84)

0.272

–

–

57.10%

0.98 (0.37-2.65)

0.973

–

–

CT/TT

70.20%

56.70%

HELB T980I

CC

70.00%

0.73 (0.30-1.80)

0.499

–

–

56.00%

1.08 (0.46-2.53)

0.859

–

–

CT/TT

63.20%

57.90%

CTDP1 T221M

CC

66.70%

1.07 (0.38-3.01)

0.090

–

–

54.60%

1.46 (0.54-3.94)

0.457

–

–

CT/TT

68.20%

63.60%

POLR2A N764K

CC CT

70.50 40.00%

0.28 (0.07-1.08)

0.065

–

–

61.50 20.00%

0.16 (0.03-0.79)

0.024

0.18 (0.03-0.98)

0.048

  1. Data in bold are those that have p < 0.05
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BMC Cancer

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