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Fig. 3 | BMC Cancer

Fig. 3

From: Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy

Fig. 3

Result of detailed SNP analysis of ABCG2 Q141K. a Domain architecture of ABCG2. ABCG2 contains a nucleotide-binding domain (NBD) in the cytoplasmic region and a membrane-spanning domain transmembrane domain (MSD) consisting of 6 putative transmembrane segments. ABCG2 Q141K is located in the NBD. b Multiple alignment using all five members in the ABCG subfamily. Orthologs of each member were retrieved from OMA browser (omabrowser.org/). MAFFT with L-INS-i was used to create the multiple alignment. We used seven representative organisms to show conservation of SNP’s region. HUMAN: H. sapiens, MACMU: M. mulatta, BOVIN: B. taurus, CANFA: C. familiaris, MOUSE: M.musculus, MONDO: M.domestica, ANOCA: A. carolinensis. c Homology model of the nucleotide-binding domain of ABCG2 using the ATP subunit of the maltose transporter from E.coli (PDB:1Q12 chain A) [37] as a template is shown in green. ATPs are shown in blue and Q141 is shown in red. Superimposition of the model and chain B of the template (shown in purple) was done to show the homodimer of the region

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