Skip to main content
Fig. 1 | BMC Cancer

Fig. 1

From: Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis

Fig. 1

ANGPTL4 is expressed in osteosarcoma and is hypoxia-inducible in osteosarcoma cell lines a 76/109 osteosarcomas expressed ANGPTL4, including 51 with low level expression and 25 with high level expression. b ANGPTL4 mRNA is high in stage 2 osteosarcoma (pre-metastatic osteosarcoma that has spread beyond the bone). c Hypoxia (0.5% O2, 18 h) induced ANGPTL4 secretion in six osteosarcoma cell lines (MG-63, MHM, HOS-143B, IOR-OS18, HOS and OSA). d, e ANGPTL4 secretion by MG-63 and OS18 cells increased in a (d) time- and (e) oxygen concentration-dependent manner. *p < 0.05, **p < 0.005, ***p < 0.001 versus the corresponding normoxic control

Back to article page