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Fig. 1 | BMC Cancer

Fig. 1

From: Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

Fig. 1

Sanguinarine inhibited the growth of orthotopic CRC in nude mice by inducing apoptosis. a Effect of sanguinarine and Cisplatin on body weight of nude mice bearing xenografts. b Photographs of tumors were from four groups. c Tumor weight of mice from Orthotopic implanted CRC model. d Tumors were dissected and tested using TUNEL staining kit (red) and DAPI (blue). The slides were observed by inverted fluorescence microscope (400×) (Scale bar is 50 μm). e Apoptosis was analyzed quantitatively by calculating percentage of the number of cells with TUNEL staining as compared to the total number of cells. f The apoptosis corresponding proteins from tumor tissue were analyzed by western blotting. g Representative photographs of H&E staining (400×) (Scale bar is 50 μm). h PCNA protein from tumor tissue was detected by western blotting. Data presented are showed as means ± SD from three independent experiments. # p < 0.01 indicates significant difference

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