Fig. 4

Screenshots of the analysis tools. a Input parameters of the “heatmap” tool. b Expression heatmap of the example genes in dataset1. Red indicates high expression and green means low expression. c Example heatmap of the somatic copy-number alterations in dataset2. Colors represent the type and number of copy number alterations. d Heatmap of the somatic mutations for 45 significantly mutated genes in dataset2. Colors represent the mutation types, such as frameshift indels, non-synonymous, splicing, stop-gain and stop-loss SNVs. e Response of 16 Hepatocellular carcinoma PDXs to Sorafenib. According to the criteria of the Division of Cancer Treatment (NCI), we defined a response as 0–20% TGI; stability as 21–50% TGI; and tumor progression as > 50% TGI. f Example result of the “differential expression analysis” tool. Genes were differentially expressed in sorafenib-sensitive and resistant groups (T-test, P < 0.01, FoldChange> 2), which may be related to the response of sorafenib