From: M1 macrophage recruitment correlates with worse outcome in SHH Medulloblastomas
Macrophage Polarization | CD86 (M1 macrophages) | CD163 (M2 macrophages) | |||
---|---|---|---|---|---|
High Expressersa | Low Expressersb | High Expressersa | Low Expressersb | ||
Number | 12 | 11 | 12 | 11 | |
Mean | 6.4 ± .6 | 2.1 ± .3 | 11.2 ± .4 | 4.6 ± .7 | |
Age | 5.0 ± 1.1 | 4.6 ± 1.5 | 5.7 ± 1.4 | 4.0 ± 1.2 | |
M:F | 7:5 | 5:6 | 7:5 | 5:6 | |
Lateral tumor location | 7 (30%) | 7 (30%) | 8 (35%) | 6 (26%) | |
Gross total resection | 10 (43%) | 6 (26%) | 9 (39%) | 7 (30%) | |
Large residual tumor (> 1.5cm2) | 1 (4%) | 3 (13%) | 2 (9%) | 2 (9%) | |
Leptomeningeal Seeding | 3 (13%) | 2 (9%) | 3 (13%) | 2 (9%) |