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Table 3 Patient characteristics according to activated macrophage recruitment in SHH

From: M1 macrophage recruitment correlates with worse outcome in SHH Medulloblastomas

Macrophage Polarization

CD86 (M1 macrophages)

 

CD163 (M2 macrophages)

 

High Expressersa

Low Expressersb

 

High Expressersa

Low Expressersb

Number

12

11

 

12

11

Mean

6.4 ± .6

2.1 ± .3

 

11.2 ± .4

4.6 ± .7

Age

5.0 ± 1.1

4.6 ± 1.5

 

5.7 ± 1.4

4.0 ± 1.2

M:F

7:5

5:6

 

7:5

5:6

Lateral tumor location

7 (30%)

7 (30%)

 

8 (35%)

6 (26%)

Gross total resection

10 (43%)

6 (26%)

 

9 (39%)

7 (30%)

Large residual tumor (> 1.5cm2)

1 (4%)

3 (13%)

 

2 (9%)

2 (9%)

Leptomeningeal Seeding

3 (13%)

2 (9%)

 

3 (13%)

2 (9%)

  1. aHigh expressers indicates patients with greater than or equal to median count.
  2. bLow expressers indicates patients with lower than median count