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Fig. 3 | BMC Cancer

Fig. 3

From: Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

Fig. 3

Apoptosis induction by sorafenib and/or selumetinib treatment. Higher apoptotic response of non-V600 BRAF mutant cell lines to the combination than to single agent treatment determined by a cleaved PARP/PARP and b, c TUNEL assay. b Representative pictures of the WM3670 cell line with TUNEL (green) and DAPI (blue) staining. Scale bar = 100 μm. c Proportion of TUNEL positive cells upon sorafenib and/or selumetinib treatment. Cells were treated with sorafenib (3 μM), selumetinib (100 nM) or the combination for 48 h (*p ≤ 0.05, * * p ≤ 0.01, * * * p ≤ 0.001)

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