Table 2 Safety evaluation
Patient no. | Toxicity of HF10 | DLT | Evaluation (CTCAE ver 4.0) | |
|---|---|---|---|---|
Cohort 1 | HF-1-02 | (−) | (−) | Grade III Neutrophil and Platlet count decrease, Duodenal stenosis, Perforative peritonitis |
HF-1-04 | (−) | (−) | Grade II fever, Blood bilirubin increase (stent failure), Interstitial pneumonia (After treatment) | |
HF-1-05 | (−) | (−) | NA | |
Cohort 2 | HF-2-01 | (−) | (−) | Grade III Neutrophil decrease |
HF-2-02 | (−) | (−) | Grade III Neutrophil decrease | |
HF-2-03 | (−) | (−) | Grade III Neutrophil decrease and Grade II ALT increase | |
Cohort 3 | HF-3-01 | (−) | (−) | Grade IV Hepatobiliary disorder |
HF-3-02 | (−) | (−) | NA | |
HF-3-03 | (−) | (−) | NA | |
HF-3-04 | (−) | (−) | Grade III Neutrophil decrease | |