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Table 1 Dose-effect relationships of single drugs and combinations in canine lymphoid cell lines

From: In vitro antineoplastic effects of auranofin in canine lymphoma cells

Cell line

Single drugs and combinations

Parameters

CI value at

DRI value at

Dm

m

r

ED50

ED75

ED90

ED95

ED50

ED75

ED90

ED95

1771

AF

0.10

−2.27

− 0.97

        
 

DOX

0.07

−1.19

− 0.96

        
 

CCNU

161.99

−1.71

−0.98

        
 

AF + DOX

0.14

−2.37

−0.99

1.44

1.68

2.03

2.38

0.93

0.91

0.89

0.87

3.00

1.74

1.10

0.81

 

AF + CCNU

73.70

−1.73

−0.88

0.81

0.77

0.73

0.71

2.80

3.24

3.76

4.16

2.20

2.18

2.16

2.14

OSW

AF

0.34

−2.09

−0.98

        
 

DOX

0.09

−1.69

−0.96

        
 

CCNU

229.43

−0.76

−100

        
 

AF + DOX

0.15

−2.29

−0.97

0.67

0.74

0.83

0.90

2.89

2.75

2.62

2.54

3.12

2.63

2.21

1.97

 

AF + CCNU

18.12

−1.96

−0.95

0.35

0.45

0.71

1.08

3.74

3.87

4.00

4.09

12.72

6.44

2.17

1.19

CLBL-1

AF

0.15

−2.22

−0.98

        
 

DOX

0.05

−1.92

−0.98

        
 

CCNU

118.01

−1.25

−0.93

        
 

AF + DOX

0.14

−2.27

−0.97

1.03

1.06

1.08

1.10

1.02

1.18

1.17

1.16

5.17

4.74

4.35

4.35

 

AF + CCNU

64.88

−1.64

−0.9

0.69

0.80

0.93

1.05

6.96

8.28

9.85

11.08

1.82

1.48

1.20

1.04

CLL-1390

AF

0.62

−1.83

−0.92

        
 

DOX

0.34

−2.28

−0.91

        
 

CCNU

235.94

−1.96

−0.97

        
 

AF + DOX

0.66

−2.67

−0.99

1.27

1.47

1.71

1.89

1.26

1.04

0.86

0.75

2.10

1.95

1.82

1.73

 

AF + CCNU

86.74

−1.87

−0.9

0.64

0.64

0.63

0.63

3.60

3.56

3.51

3.48

2.73

2.80

2.88

2.94

  1. Dm median- effect dose (concentration that inhibits cell growth by 50%), m shape of the dose-effect, r linear correlation coefficient of the median-effect plot