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Table 1 Dose-effect relationships of single drugs and combinations in canine lymphoid cell lines

From: In vitro antineoplastic effects of auranofin in canine lymphoma cells

Cell line Single drugs and combinations Parameters CI value at DRI value at
Dm m r ED50 ED75 ED90 ED95 ED50 ED75 ED90 ED95
1771 AF 0.10 −2.27 − 0.97         
  DOX 0.07 −1.19 − 0.96         
  CCNU 161.99 −1.71 −0.98         
  AF + DOX 0.14 −2.37 −0.99 1.44 1.68 2.03 2.38 0.93 0.91 0.89 0.87
3.00 1.74 1.10 0.81
  AF + CCNU 73.70 −1.73 −0.88 0.81 0.77 0.73 0.71 2.80 3.24 3.76 4.16
2.20 2.18 2.16 2.14
OSW AF 0.34 −2.09 −0.98         
  DOX 0.09 −1.69 −0.96         
  CCNU 229.43 −0.76 −100         
  AF + DOX 0.15 −2.29 −0.97 0.67 0.74 0.83 0.90 2.89 2.75 2.62 2.54
3.12 2.63 2.21 1.97
  AF + CCNU 18.12 −1.96 −0.95 0.35 0.45 0.71 1.08 3.74 3.87 4.00 4.09
12.72 6.44 2.17 1.19
CLBL-1 AF 0.15 −2.22 −0.98         
  DOX 0.05 −1.92 −0.98         
  CCNU 118.01 −1.25 −0.93         
  AF + DOX 0.14 −2.27 −0.97 1.03 1.06 1.08 1.10 1.02 1.18 1.17 1.16
5.17 4.74 4.35 4.35
  AF + CCNU 64.88 −1.64 −0.9 0.69 0.80 0.93 1.05 6.96 8.28 9.85 11.08
1.82 1.48 1.20 1.04
CLL-1390 AF 0.62 −1.83 −0.92         
  DOX 0.34 −2.28 −0.91         
  CCNU 235.94 −1.96 −0.97         
  AF + DOX 0.66 −2.67 −0.99 1.27 1.47 1.71 1.89 1.26 1.04 0.86 0.75
2.10 1.95 1.82 1.73
  AF + CCNU 86.74 −1.87 −0.9 0.64 0.64 0.63 0.63 3.60 3.56 3.51 3.48
2.73 2.80 2.88 2.94
  1. Dm median- effect dose (concentration that inhibits cell growth by 50%), m shape of the dose-effect, r linear correlation coefficient of the median-effect plot