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Table 4 Multivariate analysis of overall survival in patients

From: Loss of expression and prognosis value of alpha-internexin in gastroenteropancreatic neuroendocrine neoplasm

Factors

GEP-NENs

GI-NENs

pNENs

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Sex

1.403 (0.815–2.414)

0.222

1.261 (0.638–2.493)

0.505

0.443 (0.145–1.350)

0.152

Age (years) at diagnosis

1.332 (0.753–2.357)

0.325

1.404 (0.763–2.585)

0.275

0.373 (0.081–1.727)

0.207

Functional status

1.048 (0.352–3.120)

0.932

1.300 (0.137–12.375)

0.820

0.657 (0.155–2.789)

0.569

Tumor location

0.776 (0.406–1.484)

0.443

Tumor grade

0.106 (0.017–0.640)

0.019

0.070 (0.013–0.389)

0.002

2.473 (1.164–5.103)

0.018

Tumor type

0.468 (0.115–1.903)

0.289

6.531 (2.602–16.392)

< 0.001

1.705 (0.233–12.472)

0.599

Tumor stage

0.201 (0.083–0.489)

< 0.001

3.800 (1.522–9.487)

0.004

21.083 (2.503–177.556)

0.005

α-internexin expressiona

0.770 (0.298–1.985)

0.588

1.303 (0.241–7.058)

0.759

3.998 (0.935–17.092)

0.062

  1. aα-internexin expression means reduced/loss of expression of α-internexin
  2. GEP-NEN Gastroenteropancreatic neuroendocrine neoplasm; GI-NEN: Gastrointestinal neuroendocrine neoplasm; pNEN: Pancreatic neuroendocrine neoplasm. HR Hazard ratios, CI Confidence intervals