Fig. 4

Correlation of α-internexin methylation with overall survival. a1, b1, c1 Receiver operating characteristic (ROC) curve was used to determine a best cutoff value to define the methylation status of α-internexin in GEP-NENs, subtype of GI-NENs and pNENs. a2, b2, c2 Overall survival by α-internexin methylation (results were examined by methylation level of the average of total 12 CpG sites) in GEP-NENs, subtype of GI-NENs and pNENs. ROC: Receiver operating characteristic; AUC: Area under ROC curve; GEP-NEN: Gastroenteropancreatic neuroendocrine neoplasm; GI-NEN: Gastrointestinal neuroendocrine neoplasm; pNEN: Pancreatic neuroendocrine neoplasm