Skip to main content

Table 2 Clinical characteristics of women with neuroendocrine carcinoma of the cervix

From: Neuroendocrine carcinoma of the cervix: a systematic review of the literature

Author [Ref] Year Study type # of Cases Incidence (%) Early Stage/Advanced stage Small cell/large cell/other Immunohistochemical profile (n) Molecular characteristics (n)
Baggar [135] 2017 CR 1 1/0 1/0/0 CHG (1), CD56 (1)
Cho [34] 2017 CS 16 12/4 16/0/0 SYN (16), CHG (12), ERBB4 (16) ATRX (4/5), ERBB4 (4/5)
Damian [41] 2017 CR 1 1/0 1/0/0
Kuji [67] 2017 CS 37 30/7 29/8/0 SYN (32), CHG (32)
Paraghamian [149] 2017 CR 1 1/0 1/0/0
Wu [128] 2017 CR 1 1/0 1/0/0 SYN (1), CHG (1)
Xie [158] 2017 CS 48 40/8 31/1/16 SYN (45), NSE (25), CD56 (13)
Cavalcanti [29] 2016 CR 1 1/0/0 p53 (1), MST1R (1), MYCN Ampl. (1), U2AF1 (1), GATA3 (1)
Duan [45] 2016 CS 26 22/4 25/0/1 SYN (24), NSE (19), CD56 (13)
Frumovitz [47] 2016 COS 44 26/18 38/0/6 p53 (5), PIK3CA (8), KRAS (6)
Ganesan [48] 2016 CS 31 31/2385 (1.30%) 31/0/0
Lee [142] 2016 COS 61 41/20 41/7/13 SYN (33/43), CHG (30/43), CD56 (30/43)
Margolis [145] 2016 COS 1896 1896/127332 (1.49%) 582/1157
Rajkumar [151] 2016 CR 1 1/0 0/1/0 SYN (1), CHG (1), CD56 (1), p16 (1)
Robin [100] 2016 COS 100
Stecklein [153] 2016 COS 40 33/7 26/8/6 SYN (36), CHG (26), CD56 (14)
Majhi [79] 2015 CR 1 1/0 SYN (1), CHG (1), NSE (1)
Nagao [86] 2015 CS 23 18/5 11/12/0
Sheth [152] 2015 CR 1 1/0 1/0/0 SYN (1), CHG (1), CD56 (1)
Singh [105] 2015 CR 1 1/0 1/0/0 SYN (1), CHG (1)
Sodsanrat [109] 2015 CS 44 44/2835 (1.55%)
Wang [156] 2015 CR 1 1/0 1/0/0 SYN (1), CHG (1), CD56 (1)
Wang [157] 2015 CS 32 32/0 22/0/10
Yin [12] 2015 CS 23 18/5 23/0/0
Yuan [132] 2015 CS 38 38/0 38/0/0
Bellefqih [136] 2014 CS 6
Dongol [139] 2014 CS 4 3/1 4/0/0 SYN (4), NSE (4)
Lyons [144] 2014 CR 1 1/0 1/0/0 KRAS (1)
Omori [148] 2014 CR 1 0/1 0/1/0 SYN (1), CHG (1), CD56 (1), p16 (1), p53 (1)
Yin [129] 2014 COS 64 64/9474 (0.68%) 47/17 64/0/0
Yousef [131] 2014 CR 1 0/1 1/0/0 SYN (1)
Zaid [134] 2014 CS 57 49/8 49/8/0
Intaraphet [59] 2013 COS 130 130/2108 (6.17%) 82/48 130/0/0
Kim [63] 2013 CR 1 1/0 1/0/0 CHG (1), NSE (1)
Kuroda [69] 2013 CR 1 1/0 0/1/0 SYN (1), CD56 (1), p16 (1)
Li [76] 2013 CS 12 12/452 (2.65%) 8/4 6/6/0 SYN (11), CHG (10), CD56 (11), AE1/3 (12), p16 (11)
McCann [146] 2013 COS 26 14/12 21/2/2
Murakami [147] 2013 CR 1 0/1 0/1/0 SYN (1), CHG (1), NSE (1)
Rekhi [96] 2013 COS 50 26/14/10 SYN (22/37), CHG (27/37), NSE (7/8), CD56 (8/8)
Sitthinumsawan [108] 2013 COS 14 14/389 (3.60%) 9/5 8/3/3 SYN (11), CHG (9), NSE (12), CD56 (11)
Wang [125] 2013 CS 13 13/0/0 SYN (13), CHG (9)
Hara [54] 2012 CR 1 1/0 0/0/1 SYN (1), CHG (1), CD56 (1)
Lin [78] 2012 CS 5 4/1
Peng [150] 2012 CS 14 14/2074 (0.68%) 11/3 9/0/5
Siriaunkgul [106] 2012 CS 26 21/5 21/3/2
Sisti [107] 2012 CR 1 1/0 1/0/0 SYN (1), CHG (1), NSE (1)
Tanimoto [154] 2012 CR 1 0/1 0/1/0
Teefey [114] 2012 CR 1 1/0 1/0/0 SYN (1), CHG (1), CD56 (1), p16 (1)
Hao [53] 2011 CR 1 1/0 0/1/0 CHG (1), CD56 (1), p16 (1)
Komiyama [66] 2011 CR 1 1/0 0/0/1 SYN (1), CHG (1), NSE (1)
Nasu [13] 2011 CR 1 1/0 1/0/0
McCluggage [84] 2010 CS 21 13/8/0 SYN (19), CHG (11), CD56 (19), AE1/3 (17), p16 (21), PGP9.5 (9)
Niwa [88] 2010 CR 1 1/0 0/1/0
Rashed [95] 2010 CR 1 1/0 1/0/0 CHG (1)
Bifulco [27] 2009 CR 1 0/1 0/1/0 SYN (1), NSE (1)
Kajiwara [61] 2009 CS 7 2/5 3/2/2 SYN (7), CHG (6)
Lee [74] 2009 CR 1 1/0 1/0/0 NSE (1), CD56 (1)
Li [77] 2009 CR 1 0/1 0/1/0
Wang [123] 2009 CS 7 7/8018 (0.09%) 7/0 0/7/0
Zivanovic [159] 2009 COS 17 11/6 17/0/0
Albores-Saavedra [21] 2008 CS 2 2/0 0/2/0 SYN (2), CHG (2), CD56 (2)
Chung [36] 2008 CR 1 1/0 1/0/0 SYN (1), CHG (1), CD56 (1)
Lee [71] 2008 CS 68 68/0
Alphandery [22] 2007 CR 1 0/1 1/0/0 SYN (1), CHG (1), CD56 (1), c-Kit (1)
Kasamatsu [62] 2007 CS 10 10/2096 (0.48%) 9/1
Ko [64] 2007 CR 1 1/0 0/1/0 SYN (1), CHG (1), NSE (1)
Tangjitgamol [113] 2007 CR 1 0/1 0/1/0
Cetiner [30] 2006 CR 1 1/0 0/1/0 CHG (1), NSE (1)
Horn [56] 2006 CS 9 9/677 (1.33%) 9/0/0 SYN (7), CHG (7), NSE (7), CD56 (8), p16 (9), p53 (2)
Ohwada [89] 2006 CR 1 1/0 0/1/0 SYN (1), CHG (1), p16 (1)
Wang [124] 2006 CS 31 25/4/2
Baykal [26] 2005 CR 1 1/0 0/0/1 CHG (1), NSE (1)
Chatterjee [32] 2005 CR 1 1/0 1/0/0 NSE (1)
Tangjitgamol [112] 2005 CS 24 16/8 18/6/0
Tsunoda [117] 2005 CS 11 11/1370 (0.80%) 7/4 11/0/0 SYN (8), CHG (7), NSE (9), CD56 (6)
Dikmen [43] 2004 CR 1 1/0 0/1/0 SYN (1), CHG (1), NSE (1)
Ishida [60] 2004 CS 10 5/5/0 p53 (1)
Trinh [116] 2004 CR 1 1/0 1/0/0
Viswanathan [121] 2004 COS 21 17/4 21/0/0 SYN (19), CHG (16), CD56 (15)
Wang [8] 2004 CS 22 18/4 22/0/0 SYN (16), CHG (16), NSE (15), p16 (20), Rb loss (18)
Hoskins [14] 2003 CS 34 17/17 34/0/0
Sato [101] 2003 CS 6 6/972 (0.62%) 6/0 0/6/0 SYN (6), CHG (6)
Conner [39] 2002 CS 23 18/0/5 SYN (13), CHG (10), p53 (10)
Grayson [51] 2002 CS 12 0/12/0 SYN (11)
Marshall [83] 2002 CR 1 0/1 SYN (1)
Ribeiro-Silva [99] 2002 CR 1 1/0 0/0/1 CHG (1)
Balega [25] 2001 CR 1 1/0 SYN (1), CHG (1)
Bermúdez [15] 2001 COS 20 14/6 12/6/2 SYN (8/18), CHG (9/18), NSE (15/18)
Boruta [137] 2001 CS 11 11/0 9/1/1
Lenczewski [75] 2001 CS 6 6/73 (8.22%) 6/0/0
Rhemtula [97] 2001 CS 5 2/3 0/5/0 SYN (5), MNF116 (5)
Straughn [110] 2001 CS 16 15/1 15/0/0 SYN (8/13), CHG (8), NSE (12) p53 (8), c-myc (8/15), PCNA (5/15)
Collinet [38] 2000 CS 5 2/3 5/0/0
Delaloge [42] 2000 COS 10 7/3 10/0/0
Herrington [55] 1999 CS 25 25/0/0 Rb (2)
Koch [65] 1999 CR 1 1/0 1/0/0 SYN (1), CHG (1)
McGarry [85] 1999 CR 1 1/0 1/0/0 SYN (1), CHG (1), NSE (1)
Wistuba [127] 1999 CS 15 2/8/5 p53 (7), KRAS (0), LOH (7)
Yun [133] 1999 CR 1 1/0 0/1/0 SYN (1), CHG (1)
Mannion [80] 1998 CS 38 25/5/8 LOH (9)
Wang [155] 1998 CS 7 7/0 7/0/0 CHG (4), NSE (7)
Gilks [50] 1997 CS 12 12/0 0/12/0 SYN (6), CHG (12), NSE (4)
Toki [115] 1996 CR 1 1/0 1/0/0 CHG (1), NSE (1), SER (1)
Abulafia [19] 1995 CS 3 3/0 3/0/0  
Abeler [18] 1994 COS 26 16/10 26/0/0 SYN (7), CHG (5), NSE (19)
Chen [7] 1994 CS 6 6/0/0 NSE (6)
Lewandowski [143] 1993 CS 4 2/2 4/0/0 CHG (1), NSE (2)
Gersell [49] 1988 COS 15 10/5 15/0/0 SYN (10), CHG (11), NSE (11)
Sheets [103] 1988 COS 14 14/649 (2.16%) 14/0 14/0/0
van Nagell [120] 1988 CS 25 25/2201 (1.14%) 25/0/0 CHG (8), NSE (8)
Walker [122] 1988 CS 14 10/365 (2.74%) 8/6 12/0/2
Turner [118] 1986 CR 1 1/0 1/0/0
Pooled Analysis 3538 2303/163470 (1.41%) 1479 (50.7%)/ 1436 (49.3%) 1123 (80.0%)/ 176 (12.5%)/ 105 (7.5%) SYN (424/538; 79%), CHG (323/486; 66%), NSE (196/285; 69%), CD56 (162/267; 61%), AE1/3 (29/33; 88%), c-Kit (1/1; 100%), ERBB4 (16/16; 100%), MNF116 (5/5; 100%), p16 (67/70; 96%), p53 (13/33; 39%), PGP9.5 (9/21; 43%), Rb (2/25; 8%), Rb loss (18/22; 82%), SER (1/1; 100%) ATRX (4/5; 80%), ERBB4 (4/5; 80%), p53 (22/86; 26%), MST1R (1/1; 100%), MYCN Ampl. (1/1; 100%), U2AF1 (1/1; 100%), GATA3 (1/1; 100%), PIK3CA (8/44; 18%), KRAS (7/60; 12%), c-myc (8/15; 53%), PCNA (5/15; 33%), LOH (16/53; 30%)
  1. Abbreviations: Study types: COS cohort study, CR case report, CS case series. Immunohistochemical profile: CD56 = N-CAM; CHG chromogranin, MNF116 pan-cytokeratin antibody, NSE neuron-specific enolase, Rb retinoblastoma protein, SER Serotonin, SYN synaptophysin. Molecular characteristics, LOH loss of heterozygosity; Ampl amplified