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Table 1 Grading of neuroendocrine neoplasias of the cervix

From: Neuroendocrine carcinoma of the cervix: a systematic review of the literature

Classification/Grade Mitotic Indexa Ki-67 Indexb
Well-differentiated NEN
 NET G1 <  2/10 ≤ 2
 NET G2 2–20 3–20
 NET G3c >  20 >  20
Poorly differentiated NEN
 NEC G3 >  20 >  20
  Small cell carcinoma   
  Large cell carcinoma   
  1. According to Kim et al. [2]. NEN neuroendocrine neoplasia, NET neuroendocrine tumor, NEC neuroendocrine carcinoma
  2. aMitotic index: based on the evaluation of mitoses in 50 high-power fields (HPF; 0.2 mm2 each) in areas of higher density; expressed as mitoses per 10 high-power fields (mitoses/2 mm2)
  3. bKi-67 proliferation index: based on the evaluation of ≥500 tumor cells in areas of higher nuclear labeling (so-called hotspots)
  4. cNET G3 is defined as NET with Ki-67 proliferation index/mitotic index > 20 and without morphological features of small cell NEC or large cell NEC