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Table 2 Analysis of factors associated with survival among patients with unresectable pancreatic cancer (n = 160) (Cox proportional hazard regression analysis)

From: Impact of the treatment of pancreatic exocrine insufficiency on survival of patients with unresectable pancreatic cancer: a retrospective analysis

  Univariate analysis P value Multivariate analysis P value
HR (95% CI) HR (95% CI)
Age at diagnosis 1.03 (1.01–1.05) < 0.001 1.02 (1.00–1.03) 0.072
Gender
 Female 1.00 0.517   
 Male 0.89 (0.63–1.26)
Tumor stage
 Locally advanced tumor 1.00 0.008 1.00 0.001
 Metastatic disease 0.56 (0.37–0.86) 0.47 (0.30–0.72)
Tumor location
 Head 1.00 0.202   
 Body/tail 1.25 (0.89–1.76)
Tumor size (cm) 0.97 (0.84–1.13) 0.733   
CA 19–9 levels at diagnosis
  < 1000 U/mL 1 0.143   
  > 1000 U/mL 0.76 (0.53–1.10)
Weight loss at diagnosis
  < 10% BW 1 0.420   
  > 10% BW 0.87 (0.62–1.22)
Chemotherapy 4.68 (3.18–6.89) < 0.001 3.69 (2.33–5.85) < 0.001
PERT 1.80 (1.24–2.62) 0.002 1.81 (1.23–2.66) 0.002
  1. BW body weight, CI confidence interval, HR hazard ratio, PERT pancreatic enzyme replacement therapy