Table 2 Analysis of factors associated with survival among patients with unresectable pancreatic cancer (n = 160) (Cox proportional hazard regression analysis)
Univariate analysis | P value | Multivariate analysis | P value | |
|---|---|---|---|---|
HR (95% CI) | HR (95% CI) | |||
Age at diagnosis | 1.03 (1.01–1.05) | < 0.001 | 1.02 (1.00–1.03) | 0.072 |
Gender | ||||
Female | 1.00 | 0.517 | ||
Male | 0.89 (0.63–1.26) | |||
Tumor stage | ||||
Locally advanced tumor | 1.00 | 0.008 | 1.00 | 0.001 |
Metastatic disease | 0.56 (0.37–0.86) | 0.47 (0.30–0.72) | ||
Tumor location | ||||
Head | 1.00 | 0.202 | ||
Body/tail | 1.25 (0.89–1.76) | |||
Tumor size (cm) | 0.97 (0.84–1.13) | 0.733 | ||
CA 19–9 levels at diagnosis | ||||
< 1000 U/mL | 1 | 0.143 | ||
> 1000 U/mL | 0.76 (0.53–1.10) | |||
Weight loss at diagnosis | ||||
< 10% BW | 1 | 0.420 | ||
> 10% BW | 0.87 (0.62–1.22) | |||
Chemotherapy | 4.68 (3.18–6.89) | < 0.001 | 3.69 (2.33–5.85) | < 0.001 |
PERT | 1.80 (1.24–2.62) | 0.002 | 1.81 (1.23–2.66) | 0.002 |