Metabolite | Metabolism Pathway | Age at blood drawa (Adjusted R2) | Number of affected first-degree relatives mean levels (standard deviation) | ||||
---|---|---|---|---|---|---|---|
n = 90 | P-valueb | 1 (n = 27) | 2 (n = 25) | 3 (n = 38) | P-valueb | ||
1-(1-enyl-palmitoyl)-2-oleoyl-GPC (P-16:0/18:1)3 | Plasmalogen | 0.13 | < 0.01 | 1.02 (0.24) | 0.98 (0.27) | 1.16 (0.38) | 0.02 |
1-linoleoyl-GPA (18:2) c | Lysolipid | 0.01 | 0.29 | 0.97 (0.51) | 1.22 (0.64) | 1.39 (1.11) | 0.06 |
1-palmitoleoyl-2-linoleoyl-GPC (16:1/18:2) 3 | Phospholipid | 0.01 | 0.23 | 1.15 (0.56) | 1.04 (0.42) | 1.01 (0.45) | 0.75 |
1-palmitoyl-GPG (16:0) c | Lysolipid | < 0.01 | 0.92 | 0.78 (0.53) | 0.93 (0.98) | 1.05 (0.91) | 0.23 |
1-palmitoylglycerol (16:0) | Monoacylglycerol | 0.07 | 0.02 | 1.07 (0.39) | 0.93 (0.31) | 1.22 (0.59) | 0.001 |
2-ethylphenylsulfate | Benzoate | < 0.01 | 0.38 | 0.68 (0.51) | 0.97 (0.92) | 0.64 (0.51) | 0.001 |
3-(cystein-S-yl)acetaminophenc | Xanthine | < 0.01 | 0.96 | 0.50 (1.08) | 0.22 (0.08) | 0.47 (1.38) | 0.12 |
4-acetylphenol sulfate | Drug | 0.01 | 0.71 | 0.82 (0.64) | 1.24 (2.78) | 1.60 (3.83) | 0.35 |
adrenate (22:4n6) | Polyunsaturated fatty acid (n3 and n6) | < 0.01 | 0.78 | 1.28 (0.61) | 0.83 (0.62) | 1.13 (0.66) | 0.78 |
asparagine | Alanine and aspartate | 0.04 | 0.06 | 1.01 (0.32) | 1.14 (0.39) | 1.08 (0.27) | 0.15 |
cysteine s-sulfate | Glycogen | 0.09 | 0.01 | 3.81 (6.30) | 4.89 (6.51) | 4.28 (7.47) | 0.8 |
cysteinylglycine | Glutathione | 0.01 | 0.24 | 1.05 (0.50) | 1.10 (0.68) | 1.15 (0.67) | 0.2 |
ergothioneine | Food component/plant | < 0.01 | 0.36 | 1.24 (0.91) | 1.04 (0.55) | 1.35 (1.46) | 0.21 |
glycerate | Glycolysis, Gluconeogenesis, and Pyruvate | < 0.01 | 0.57 | 1.09 (0.45) | 1.35 (0.94) | 1.23 (0.56) | 0.03 |
glycolithocholate | Secondary bile acid | 0.01 | 0.20 | 0.94 (1.08) | 1.03 (1.78) | 0.82 (0.98) | 0.66 |
heptanoate (7:0) | Medium chain fatty acid | < 0.01 | 0.64 | 1.06 (1.15) | 0.86 (1.07) | 0.72 (0.54) | 0.24 |
indoleacetate | Tryptophan | 0.01 | 0.57 | 1.23 (0.75) | 1.43 (0.98) | 1.19 (0.89) | 0.71 |
indoleacetylglutamine | Tryptophan | < 0.01 | 0.39 | 1.75 (6.23) | 0.77 (0.89) | 0.74 (0.56) | 0.05 |
laurylcarnitine | Fatty acid (acyl carnitine) | 0.03 | 0.12 | 1.62 (2.24) | 0.92 (0.60) | 1.15 (0.66) | 0.08 |
maltotriose | Glycogen | 0.04 | 0.10 | 1.17 (0.51) | 1.05 (0.56) | 0.93 (0.47) | 0.92 |
N-(2-furoyl)glycine | Food component/plant | 0.02 | 0.38 | 3.87 (7.12) | 1.62 (3.61) | 4.07 (6.35) | 0.03 |
sphingosine | Sphingolipid | < 0.01 | 0.62 | 1.03 (0.60) | 0.91 (0.53) | 1.12 (1.29) | 0.06 |
sphingosine 1-phosphate | Sphingolipid | 0.03 | 0.12 | 1.08 (0.49) | 0.98 (0.41) | 0.98 (0.50) | 0.32 |
threonine | Glycine, serine, and threonine | 0.05 | 0.05 | 0.97 (0.22) | 1.03 (0.32) | 1.05 (0.22) | 0.07 |