Metabolomic profiles in breast cancer:a pilot case-control study in the breast cancer family registry

Dougan, Marcelle M.; Li, Yuqing; Chu, Lisa W.; Haile, Robert W.; Whittemore, Alice S.; Han, Summer S.; Moore, Steven C.; Sampson, Joshua N.; Andrulis, Irene L.; John, Esther M.; Hsing, Ann W.

doi:10.1186/s12885-018-4437-z

BMC Cancer

Table 3 Differences by key breast cancer risk factors among metabolites that showed a greater than 20% case-control difference

From: Metabolomic profiles in breast cancer:a pilot case-control study in the breast cancer family registry

Metabolite	Metabolism Pathway	Age at blood draw^a (Adjusted R²)		Number of affected first-degree relatives mean levels (standard deviation)
		n = 90	P-value^b	1 (n = 27)	2 (n = 25)	3 (n = 38)	P-value^b
1-(1-enyl-palmitoyl)-2-oleoyl-GPC (P-16:0/18:1)³	Plasmalogen	0.13	< 0.01	1.02 (0.24)	0.98 (0.27)	1.16 (0.38)	0.02
1-linoleoyl-GPA (18:2) ^c	Lysolipid	0.01	0.29	0.97 (0.51)	1.22 (0.64)	1.39 (1.11)	0.06
1-palmitoleoyl-2-linoleoyl-GPC (16:1/18:2) ³	Phospholipid	0.01	0.23	1.15 (0.56)	1.04 (0.42)	1.01 (0.45)	0.75
1-palmitoyl-GPG (16:0) ^c	Lysolipid	< 0.01	0.92	0.78 (0.53)	0.93 (0.98)	1.05 (0.91)	0.23
1-palmitoylglycerol (16:0)	Monoacylglycerol	0.07	0.02	1.07 (0.39)	0.93 (0.31)	1.22 (0.59)	0.001
2-ethylphenylsulfate	Benzoate	< 0.01	0.38	0.68 (0.51)	0.97 (0.92)	0.64 (0.51)	0.001
3-(cystein-S-yl)acetaminophen^c	Xanthine	< 0.01	0.96	0.50 (1.08)	0.22 (0.08)	0.47 (1.38)	0.12
4-acetylphenol sulfate	Drug	0.01	0.71	0.82 (0.64)	1.24 (2.78)	1.60 (3.83)	0.35
adrenate (22:4n6)	Polyunsaturated fatty acid (n3 and n6)	< 0.01	0.78	1.28 (0.61)	0.83 (0.62)	1.13 (0.66)	0.78
asparagine	Alanine and aspartate	0.04	0.06	1.01 (0.32)	1.14 (0.39)	1.08 (0.27)	0.15
cysteine s-sulfate	Glycogen	0.09	0.01	3.81 (6.30)	4.89 (6.51)	4.28 (7.47)	0.8
cysteinylglycine	Glutathione	0.01	0.24	1.05 (0.50)	1.10 (0.68)	1.15 (0.67)	0.2
ergothioneine	Food component/plant	< 0.01	0.36	1.24 (0.91)	1.04 (0.55)	1.35 (1.46)	0.21
glycerate	Glycolysis, Gluconeogenesis, and Pyruvate	< 0.01	0.57	1.09 (0.45)	1.35 (0.94)	1.23 (0.56)	0.03
glycolithocholate	Secondary bile acid	0.01	0.20	0.94 (1.08)	1.03 (1.78)	0.82 (0.98)	0.66
heptanoate (7:0)	Medium chain fatty acid	< 0.01	0.64	1.06 (1.15)	0.86 (1.07)	0.72 (0.54)	0.24
indoleacetate	Tryptophan	0.01	0.57	1.23 (0.75)	1.43 (0.98)	1.19 (0.89)	0.71
indoleacetylglutamine	Tryptophan	< 0.01	0.39	1.75 (6.23)	0.77 (0.89)	0.74 (0.56)	0.05
laurylcarnitine	Fatty acid (acyl carnitine)	0.03	0.12	1.62 (2.24)	0.92 (0.60)	1.15 (0.66)	0.08
maltotriose	Glycogen	0.04	0.10	1.17 (0.51)	1.05 (0.56)	0.93 (0.47)	0.92
N-(2-furoyl)glycine	Food component/plant	0.02	0.38	3.87 (7.12)	1.62 (3.61)	4.07 (6.35)	0.03
sphingosine	Sphingolipid	< 0.01	0.62	1.03 (0.60)	0.91 (0.53)	1.12 (1.29)	0.06
sphingosine 1-phosphate	Sphingolipid	0.03	0.12	1.08 (0.49)	0.98 (0.41)	0.98 (0.50)	0.32
threonine	Glycine, serine, and threonine	0.05	0.05	0.97 (0.22)	1.03 (0.32)	1.05 (0.22)	0.07

^aThe age models for all metabolites were fitted with a linear and a quadratic term, with the exception of maltitriose, which also included a cubic term for age, as the model fit was improved for this metabolite over the liner and quadratic model
^bNot adjusted for multiple comparisons
^cIndicates compounds that have not been officially confirmed based on a standard, although identity is certain
Significant data are in bold

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