Skip to main content

Table 3 Differences by key breast cancer risk factors among metabolites that showed a greater than 20% case-control difference

From: Metabolomic profiles in breast cancer:a pilot case-control study in the breast cancer family registry

Metabolite Metabolism Pathway Age at blood drawa (Adjusted R2) Number of affected first-degree relatives mean levels (standard deviation)
   n = 90 P-valueb 1 (n = 27) 2 (n = 25) 3 (n = 38) P-valueb
1-(1-enyl-palmitoyl)-2-oleoyl-GPC (P-16:0/18:1)3 Plasmalogen 0.13 < 0.01 1.02 (0.24) 0.98 (0.27) 1.16 (0.38) 0.02
1-linoleoyl-GPA (18:2) c Lysolipid 0.01 0.29 0.97 (0.51) 1.22 (0.64) 1.39 (1.11) 0.06
1-palmitoleoyl-2-linoleoyl-GPC (16:1/18:2) 3 Phospholipid 0.01 0.23 1.15 (0.56) 1.04 (0.42) 1.01 (0.45) 0.75
1-palmitoyl-GPG (16:0) c Lysolipid < 0.01 0.92 0.78 (0.53) 0.93 (0.98) 1.05 (0.91) 0.23
1-palmitoylglycerol (16:0) Monoacylglycerol 0.07 0.02 1.07 (0.39) 0.93 (0.31) 1.22 (0.59) 0.001
2-ethylphenylsulfate Benzoate < 0.01 0.38 0.68 (0.51) 0.97 (0.92) 0.64 (0.51) 0.001
3-(cystein-S-yl)acetaminophenc Xanthine < 0.01 0.96 0.50 (1.08) 0.22 (0.08) 0.47 (1.38) 0.12
4-acetylphenol sulfate Drug 0.01 0.71 0.82 (0.64) 1.24 (2.78) 1.60 (3.83) 0.35
adrenate (22:4n6) Polyunsaturated fatty acid (n3 and n6) < 0.01 0.78 1.28 (0.61) 0.83 (0.62) 1.13 (0.66) 0.78
asparagine Alanine and aspartate 0.04 0.06 1.01 (0.32) 1.14 (0.39) 1.08 (0.27) 0.15
cysteine s-sulfate Glycogen 0.09 0.01 3.81 (6.30) 4.89 (6.51) 4.28 (7.47) 0.8
cysteinylglycine Glutathione 0.01 0.24 1.05 (0.50) 1.10 (0.68) 1.15 (0.67) 0.2
ergothioneine Food component/plant < 0.01 0.36 1.24 (0.91) 1.04 (0.55) 1.35 (1.46) 0.21
glycerate Glycolysis, Gluconeogenesis, and Pyruvate < 0.01 0.57 1.09 (0.45) 1.35 (0.94) 1.23 (0.56) 0.03
glycolithocholate Secondary bile acid 0.01 0.20 0.94 (1.08) 1.03 (1.78) 0.82 (0.98) 0.66
heptanoate (7:0) Medium chain fatty acid < 0.01 0.64 1.06 (1.15) 0.86 (1.07) 0.72 (0.54) 0.24
indoleacetate Tryptophan 0.01 0.57 1.23 (0.75) 1.43 (0.98) 1.19 (0.89) 0.71
indoleacetylglutamine Tryptophan < 0.01 0.39 1.75 (6.23) 0.77 (0.89) 0.74 (0.56) 0.05
laurylcarnitine Fatty acid (acyl carnitine) 0.03 0.12 1.62 (2.24) 0.92 (0.60) 1.15 (0.66) 0.08
maltotriose Glycogen 0.04 0.10 1.17 (0.51) 1.05 (0.56) 0.93 (0.47) 0.92
N-(2-furoyl)glycine Food component/plant 0.02 0.38 3.87 (7.12) 1.62 (3.61) 4.07 (6.35) 0.03
sphingosine Sphingolipid < 0.01 0.62 1.03 (0.60) 0.91 (0.53) 1.12 (1.29) 0.06
sphingosine 1-phosphate Sphingolipid 0.03 0.12 1.08 (0.49) 0.98 (0.41) 0.98 (0.50) 0.32
threonine Glycine, serine, and threonine 0.05 0.05 0.97 (0.22) 1.03 (0.32) 1.05 (0.22) 0.07
  1. aThe age models for all metabolites were fitted with a linear and a quadratic term, with the exception of maltitriose, which also included a cubic term for age, as the model fit was improved for this metabolite over the liner and quadratic model
  2. bNot adjusted for multiple comparisons
  3. cIndicates compounds that have not been officially confirmed based on a standard, although identity is certain
  4. Significant data are in bold