Skip to main content

Table 2 Univariate and multivariate analyses of prognostic parameters in 183 HCC patients by Cox-regression analysis

From: VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

Variables Univariate Multivariate
P HR (95% CI) P HR (95% CI)
Gender
 Male versus Female 0.146 1.562 (0.856–2.851)   
Age(year)
  > 50 versus ≤50 0.787 1.055 (0.714–1.561)   
Tumor size (cm)
  ≤ 5 versus > 5 0.002* 1.847 (1.252–2.724) 0.218 1.314 (0.851–2.028)
TNM stage
 I versus II versus III-IV 0.000* 1.617 (1.258–2.077) 0.001* 1.627 (1.235–2.143)
Pathological grade
 I-II versus III-IV 0.748 1.068 (0.717–1.590)   
Liver cirrhosis
 Yes versus No 0.460 0.862 (0.582–1.277)   
VISTA
 Positive versus Negative 0.139 0.720 (0.466–1.113)   
VISTA (tumor cell)
 Positive versus Negative 0.038* 0.536 (0.297–0.966) 0.128 0.610 (0.323–1.152)
VISTA (immune cell)
 Positive versus Negative 0.890 1.036 (0.630–1.703)   
CD8+TILs
 Positive versus Negative 0.008* 0.556 (0.361–0.858) 0.024* 0.586 (0.368–0.932)
  1. VISTA V-domain Ig suppressor of T cell activation, HCC hepatocellular carcinoma, TILs tumor-infiltrating lymphocytes, HR hazard radio, CI confidence internal
  2. *The values had statistically significant differences