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Table 2 Univariate and multivariate analyses of prognostic parameters in 183 HCC patients by Cox-regression analysis

From: VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma

Variables

Univariate

Multivariate

P

HR (95% CI)

P

HR (95% CI)

Gender

 Male versus Female

0.146

1.562 (0.856–2.851)

  

Age(year)

  > 50 versus ≤50

0.787

1.055 (0.714–1.561)

  

Tumor size (cm)

  ≤ 5 versus > 5

0.002*

1.847 (1.252–2.724)

0.218

1.314 (0.851–2.028)

TNM stage

 I versus II versus III-IV

0.000*

1.617 (1.258–2.077)

0.001*

1.627 (1.235–2.143)

Pathological grade

 I-II versus III-IV

0.748

1.068 (0.717–1.590)

  

Liver cirrhosis

 Yes versus No

0.460

0.862 (0.582–1.277)

  

VISTA

 Positive versus Negative

0.139

0.720 (0.466–1.113)

  

VISTA (tumor cell)

 Positive versus Negative

0.038*

0.536 (0.297–0.966)

0.128

0.610 (0.323–1.152)

VISTA (immune cell)

 Positive versus Negative

0.890

1.036 (0.630–1.703)

  

CD8+TILs

 Positive versus Negative

0.008*

0.556 (0.361–0.858)

0.024*

0.586 (0.368–0.932)

  1. VISTA V-domain Ig suppressor of T cell activation, HCC hepatocellular carcinoma, TILs tumor-infiltrating lymphocytes, HR hazard radio, CI confidence internal
  2. *The values had statistically significant differences
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BMC Cancer

ISSN: 1471-2407

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