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Table 5 Diagnostic accuracy of MTV and ASP towards IR (TG/TL)

From: Pretherapeutic FDG-PET total metabolic tumor volume predicts response to induction therapy in pediatric Hodgkin’s lymphoma

  TG/TL 1 TG/TL 2 TG/TL 3
Parameter Sens. (95%-CI) Spec. (95%-CI) Sens. (95%-CI) Spec. (95%-CI) Sens. (95%-CI) Spec. (95%-CI)
NPV (95%-CI) PPV (95%-CI) NPV (95%-CI) PPV (95%-CI) NPV (95%-CI) PPV (95%-CI)
MTV 100% (54 to 100%) 83% (36 to 100%) 80% (44 to 97%) 71% (29 to 96%) 75% (43 to 95%) 89% (52 to 100%)
100% (48 to 100%) 86% (42 to 100%) 71% (29 to 96%) 80% (44 to 97%) 73% (39 to 94%) 90% (55 to 100%)
ASP 83% (36 to 100%) 67% (22 to 96%) 80% (44 to 97%) 43% (10 to 82%) 58% (28 to 85%) 78% (40 to 97%)
80% (28 to 99%) 71% (29 to 96%) 60% (15 to 95%) 67% (35 to 90%) 58% (28 to 85%) 78% (40 to 97%)
  1. TG/TL treatment group/level, Sens. sensitivity, 95%-CI 95%-confidence interval, spec. Specificity, NPV negative predictive value, PPV positive predictive value, MTV metabolic tumor volume, ASP asphericity