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Table 4 Results of ROC analysis separated by TG/TL

From: Pretherapeutic FDG-PET total metabolic tumor volume predicts response to induction therapy in pediatric Hodgkin’s lymphoma

  TG/TL 1 TG/TL 2 TG/TL 3
AUC (95%-CI) Optimal cut-off value AUC (95%-CI) Optimal cut-off value AUC (95%-CI) Optimal cut-off value
Metabolic parameters
 MTV 0.92 (0.74 to 1.0) > 80 ml 0.71 (0.44 to 0.99) > 160 ml 0.85 (0.69 to 1.0) > 410 ml
 SUVmax 0.47 (0.1 to 0.86) > 7.5 0.61 (0.29 to 0.94) > 13.9 0.67 (0.43 to 0.91) > 13.8
 SUVmean 0.39 (0.0 to 0.76) > 3.3 0.73 (0.49 to 0.97) > 6.6 0.69 (0.46 to 0.93) > 5.9
 SUVpeak 0.42 (0.0 to 0.79) > 5.3 0.6 (0.28 to 0.92) > 12.3 0.71 (0.48 to 0.94) > 12.6
 TLG 0.89 (0.7 to 1.0) > 320 ml 0.66 (0.38 to 0.93) > 890 ml 0.85 (0.69 to 1.0) > 2800 ml
Heterogeneity parameters
 ASP 0.78 (0.49 to 1.0) > 137% 0.5 (0.2 to 0.8) > 90% 0.7 (0.48 to 0.93) > 235%
 Entropy 0.61 (0.27 to 0.95) < 5.9 0.53 (0.22 to 0.84) < 5.82 0.51 (0.25 to 0.77) < 5.73
 Contrast 0.78 (0.51 to 1.0) < 39 0.54 (0.24 to 0.85) < 17.6 0.61 (0.35 to 0.87) < 19
 Local homogeneity 0.67 (0.34 to 1.0) > 21.8 0.43 (0.11 to 0.75) > 23.3 0.64 (0.38 to 0.9) > 30.4
 Energy 0.58 (0.23 to 0.93) > 0.37 0.54 (0.23 to 0.85) > 0.41 0.48 (0.22 to 0.75) > 0.51
 CSH 0.33 (0.0 to 0.67) > 0.52 0.63 (0.32 to 0.94) > 0.44 0.51 (0.25 to 0.77) > 0.41
  1. TG/TL treatment group / level, 95%-CI 95%-confidence interval, MTV metabolic tumor volume, TLG total lesion glycolysis, ASP asphericity, CSH cumulative SUV-volume histograms