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Table 3 Diagnostic accuracy of MTV and ASP towards IR (stages)

From: Pretherapeutic FDG-PET total metabolic tumor volume predicts response to induction therapy in pediatric Hodgkin’s lymphoma

  Stage I/II Stage III/IV
Parameter Sens. (95%-CI) Spec. (95%-CI) Sens. (95%-CI) Spec. (95%-CI)
NPV (95%-CI) PPV (95%-CI) NPV (95%-CI) PPV (95%-CI)
MTV 94% (70 to 100%) 64% (31 to 89%) 75% (43 to 95%) 91% (59 to 100%)
88% (47 to 100%) 79% (54 to 94%) 77% (46 to 95%) 90% (55 to 100%)
ASP 81% (54 to 96%) 55% (23 to 83%) 83% (52 to 98%) 64% (31 to 89%)
67% (30 to 93%) 72% (47 to 90%) 78% (40 to 97%) 71% (42 to 92%)
  1. Sens. sensitivity, 95%-CI 95%-confidence interval, spec. Specificity, NPV negative predictive value, PPV positive predictive value, MTV metabolic tumor volume, ASP asphericity