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Table 2 Results of ROC analysis separated by stage

From: Pretherapeutic FDG-PET total metabolic tumor volume predicts response to induction therapy in pediatric Hodgkin’s lymphoma

  Stage I/II Stage III/IV
AUC (95%-CI) Optimal cut-off value AUC (95%-CI) Optimal cut-off value
Metabolic parameters
 MTV 0.84 (0.69 to 0.99) > 80 ml 0.86 (0.7 to 1.0) > 410 ml
 SUVmax 0.56 (0.33 to 0.8) > 10.2 0.71 (0.5 to 0.93) > 13.8
 SUVmean 0.61 (0.39 to 0.83) > 4.1 0.71 (0.5 to 0.93) > 5.9
 SUVpeak 0.58 (0.35 to 0.81) > 9.1 0.74 (0.53 to 0.95) > 12.6
 TLG 0.77 (0.58 to 0.97) > 450 ml 0.86 (0.7 to 1.0) > 2800 ml
Heterogeneity parameters
 ASP 0.65 (0.43 to 0.88) > 92% 0.74 (0.54 to 0.95) > 210%
 Entropy 0.58 (0.35 to 0.81) < 5.82 0.58 (0.33 to 0.82) < 5.73
 Contrast 0.67 (0.45 to 0.89) < 25 0.66 (0.43 to 0.89) < 16
 Local homogeneity 0.58 (0.33 to 0.83) > 24 0.68 (0.45 to 0.91) > 30.4
 Energy 0.58 (0.34 to 0.82) > 0.394 0.55 (0.31 to 0.8) > 0.51
 CSH 0.49 (0.25 to 0.74) > 0.44 0.46 (0.21 to 0.7) > 0.44
  1. MTV metabolic tumor volume, 95%-CI 95%-confidence interval, TLG total lesion glycolysis, ASP asphericity, CSH cumulative SUV-volume histograms