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Table 3 Multivariate Cox Regression for the whole cohort, the Right-sided cohort and the Left-sided cohort

From: Prognostic value of total number of lymph nodes retrieved differs between left-sided colon cancer and right-sided colon cancer in stage III patients with colon cancer

Patients Characteristics Full cohort Right-sided Left-sided
HR (95% CI) P HR (95% CI) P HR (95% CI) P
Age at diagnosis   < 0.001   < 0.001   < 0.001
 < 40 1.000   1.000   1.000  
 40–49 1.074 (0.962–1.199) 0.201 1.019 (0.875–1.187) 0.809 1.146 (0.977–1.343) 0.094
 50–59 1.144 (1.035–1.264) .0.008 1.162 (1.014–1.333) 0.031 1.107 (0.956–1.281) 0.174
 60–69 1.466 (1.330–1.616) < 0.001 1.422 (1.245–1.624) < 0.001 1.462 (1.266–1.688) < 0.001
 > 70 2.516 (2.287–2.769) < 0.001 2.265 (1.987–2.581) < 0.001 2.878 (2.500–3.312) < 0.001
Sex
 Female vs. Male 0.804 (0.784–0.825) < 0.001    0.796 (0.762–0.833) < 0.001
Race   < 0.001   < 0.001   < 0.001
 Black 1.000   1.000   1.000  
 White 0.866 (0.834–0.898) < 0.001 0.907 (0.866–0.950) < 0.001 0.797 (0.749–0.848) < 0.001
 Hispanic/Latino 0.848 (0.718–1.001) 0.051 0.856 (0.696–1.052) 0.140 0.825 (0.625–1.090) 0.175
 Asian or Pacific Islander and others 0.687 (0.647–0.729) < 0.001 0.699 (0.646–0.757) < 0.001 0.663 (0.606–0.726) < 0.001
 Unknown 0.471 (0.339–0.654) < 0.001 0.482 (0.317–0.734) 0.001 0.462 (0.273–0.783) 0.004
Hispanic
 Yes vs. No 0.920 (0.881–0.962) < 0.001 0.906 (0.857–0.958) < 0.001   
T stage   < 0.001     < 0.001
 T0-T2 (0, 2, 3) 1.000   1.00   1.000  
 T3-T4 (4, 5) 1.703 (1.629–1.780) < 0.001 1.540 (1.458–1.627) < 0.001 1.984 (1.841–2.138) < 0.001
 TX (6) 1.366 (0.933–1.999) 0.109 1.155 (0.693–1.926) 0.580 1.756 (0.991–3.112) 0.054
N stage
 N2 vs. N1 1.139 (1.097–1.181) < 0.001 1.157 (1.105–1.211) < 0.001 1.063 (1.005–1.124) 0.033
Chemotherapy
 Yes vs. No 0.499 (0.486–0.513) < 0.001 0.501 (0.485–0.517) < 0.001 0.491 (0.469–0.513) < 0.001
Radiotherapy     < 0.001   
 No 1.000   1.000   1.000  
 Yes 1.286 (1.017–1.626) 0.036 1.402 (1.031–1.906) 0.031 1.253 (0.865–1.816) 0.233
 Unknown 0.866 (0.696–1.077) 0.196 0.851 (0.644–1.123) 0.254 0.886 (0.623–1.262) 0.503
Marital status   < 0.001   < 0.001   < 0.001
 Single, separated, divorced, 1.000   1.000   1.000  
 Married (including common law) 0.785 (0.761–0.811) < 0.001 0.844 (0.811–0.878) < 0.001 0.733 (0.695–0.773) < 0.001
 Windowed 1.078 (1.039–1.120) < 0.001 1.051 (1.005–1.099) < 0.001 1.029 (0.963–1.099) 0.399
 Unknown 0.875 (0.818–0.936) < 0.001 0.904 (0.834–0.981) 0.015 0.812 (0.720–0.916) 0.001
Pathology grade   < 0.001   < 0.001   < 0.001
 Well-differentiated 1.000   1.000   1.000  
 Moderately differentiated 1.086 (1.025–1.151) 0.005 1.145 (1.063–1.233) < 0.001 1.003 (0.915–1.101) 0.942
 Poorly differentiated 1.340 (1.262–1.424) < 0.001 1.378 (1.276–1.487) < 0.001 1.282 (1.160–1.417) < 0.001
 Undifferentiated 1.636 (1.507–1.777) < 0.001 1.658 (1.502–1.830) < 0.001 1.639 (1.393–1.928) < 0.001
 Unknown 1.228 (1.115–1.352) < 0.001 1.275 (1.133–1.435) < 0.001 1.157 (0.979–1.368) 0.087
Tumor site
 Left-sided vs. Right-sided 0.847 (0.824–0.870) < 0.001     
Lymph nodes ratio   < 0.001   < 0.001   < 0.001
 < 0.07 1.000   1.000   1.000  
 0.07–0.25 1.277 (1.229–1.325) < 0.001 1.294 (1.236–1.354) < 0.001 1.245 (1.167–1.328) < 0.001
 0.25–0.50 1.602 (1.523–1.685) < 0.001 1.663 (1.563–1.770) < 0.001 1.514 (1.402–1.636) < 0.001
 0.50–1.0 2.494 (2.357–2.640) < 0.001 2.671 (2.491–2.863) < 0.001 2.282 (2.100–2.480) < 0.001
aTotal number of lymph nodes (without Lymph nodes ratio)
  ≥ 12 vs. < 12 0.747 (0.728–0.766) < 0.001 0.706 (0.683–0.730) < 0.001 0.780 (0.747–0.815) < 0.001
Total number of lymph nodes (with Lymph nodes ratio)
 ≥ 12 vs. < 12 0.938 (0.909–0.967) < 0.001 0.902 (0.886–0.957) < 0.001 0.968 (0.919–1.020) 0.223
bTotal number of lymph nodes (without Lymph nodes ratio) 1.000 (0.998–1.001) 0.694 0.981 (0.980–0.983) < 0.001 0.985 (0.982–0.987) < 0.001
Total number of lymph nodes (with Lymph nodes ratio) 1.004 (1.003–1.006) < 0.001 0.994 (0.992–0.997) < 0.001 0.996 (0.993–1.000) 0.033
cTotal number of lymph nodes (without Lymph nodes ratio)
  ≥ 11 vs. < 11      0.704 (0.669–0.740) < 0.001
Total number of lymph nodes (with Lymph nodes ratio)
  ≥ 11 vs. < 11      0.868 (0.813–0.927) < 0.001
  1. Abbreviations: aTotal number of lymph nodes as a Categorical variable
  2. bTotal number of lymph nodes as a continuous variable
  3. cThe threshold is 11 in the Left-sided cohort