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Table 2 Univariate Cox regression analysis of the whole cohort, the Right-sided cohort, and the Left-sided cohort

From: Prognostic value of total number of lymph nodes retrieved differs between left-sided colon cancer and right-sided colon cancer in stage III patients with colon cancer

Patients Characteristics Full cohort Right-sided Left-sided
HR (95% CI) P HR (95% CI) P HR (95% CI) P
Age at diagnosis   < 0.001   < 0.001   < 0.001
  < 40 1.000   1.000   1.000  
 40–49 1.101 (0.987–1.229) 0.319 1.080 (0.928–1.258) 0.319 1.126 (0.961–1.320) 0.143
 50–59 1.158 (1.048–1.279) 0.007 1.205 (1.051–1.381) 0.007 1.086 (0.938–1.256) 0.270
 60–69 1.557 (1.414–1.716) < 0.001 1.499 (1.313–1.711) < 0.001 1.523 (1.321–1.757) < 0.001
  > 70 3.364 (3.063–3.695) < 0.001 2.999 (2.636–3.411) < 0.001 3.646 (3.178–4.183) < 0.001
Gender
 Female vs. Male 0.989 (0.960–1.019) 0.018 0.475 0.875 0.839–0.913 < 0.001
Race   < 0.001   < 0.001   < 0.001
 Black 1.000   1.000   1.000  
 White 0.994 (0.959–1.031) 0.756 1.056 (1.010–1.105) 0.017 0.879 (0.827–0.935) < 0.001
 Hispanic/Latino 0.861 (0.730–1.016) 0.077 0.913 (0.743–1.122) 0/388 0.793 (0.601–1.046) 0.101
 Asian or Pacific Islander and others 0.699 (0.659–0.742) < 0.001 0.766 (0.708–0.828) < 0.001 0.671 (0.614–0.734) < 0.001
 Unknown 0.445 (0.320–0.618) < 0.001 0.449 (0.295–0.684) < 0.001 0.449 (0.265–0.761) 0.003
Hispanic
 Yes vs. No 0.834 (0.799–0.871) < 0.001 0.838 (0.793–0.885) < 0.001 0.857 (0.798–0.921) < 0.001
T stage   < 0.001   < 0.001   < 0.001
 T0–T2 (0, 2, 3) 1.000   1.000   1.000  
 T3–T4 (4, 5) 1.973 (1.889–2.061) < 0.001 1.784 (1.690–1.883) < 0.001 2.212 2.055–2.381
 TX (6) 1.315 (0.900–1.922) 0.157 1.188 (0.714–1.976) 0.507 1.575 (0.891–2.786) 0.118
N stage
 N2 vs. N1 1.581 (1.543–1.620) < 0.001 1.657 (1.608–1.707) < 0.001 1.415 (1.355–1.477) < 0.001
Chemotherapy
 Yes vs. No 0.408 (0.398–0.418) < 0.001 0.430 (0.417–0.443) < 0.001 0.386 (0.370–0.403) < 0.001
Radiotherapy   < 0.001   < 0.001   0.001
 No 1.000   1.000   1.000  
 Yes 0.517 (0.410–0.654) < 0.001 0.637 (0.469–0.865) 0.004 0.508 (0.351–0.735) < 0.001
 Unknown 0.524 (0.421–0.651) < 0.001 0.515 (0.390–0.680) < 0.001 0.506 (0.356–0.721) < 0.001
Marital status   < 0.001   < 0.001   < 0.001
 Single, separated, divorced, 1.000   1.000   1.000  
 Married (including common law) 0.843 (0.818–0.870) < 0.001 0.872 (0.839–0.907) < 0.001 0.788 (0.748–0.829) < 0.001
 Widowed 1.681 (1.623–1.740) < 0.001 1.592 (1.524–1.659) < 0.001 1.746 (1.643–1.856) < 0.001
 Unknown 1.065 (0.996–1.139) 0.065 1.082 (0.998–1.173) 0.056 0.984 (0.873–1.110) 0.792
Pathology grade   < 0.001   < 0.001   < 0.001
 Well-differentiated 1.000   1.000   1.000  
 Moderately differentiated 1.119 (1.056–1.186) < 0.001 1.197 (1.112–1.289) < 0.001 1.020 (0.930–1.119) 0.669
 Poorly differentiated 1.635 (1.540–1.736) < 0.001 1.673 (1.551–1.804) < 0.001 1.436 (1.300–1.586) < 0.001
 Undifferentiated 1.981 (1.825–2.150) < 0.001 1.988 (1.802–2.192) < 0.001 1.735 (1.476–2.040) < 0.001
 Unknown 1.308 (1.188–1.439) < 0.001 1.403 (1.247–1.578) < 0.001 1.113 (0.942–1.315) 0.208
Positive lymph node   < 0.001   < 0.001   < 0.001
 0 1.000   1.000   1.000  
 1 0.943 (0.851–1.045) 0.265 0.933 (0.819–1.062) 0.293 0.932 (0.787–1.105) 0.418
 2–3 1.085 (0.979–1.202) 0.121 1.082 (0.951–1.232) 0.232 1.058 (0.893–1.253) 0.514
 4–6 1.347 (1.215–1.495) < 0.001 1.385 (1.216–1.578) < 0.001 1.236 (1.041–1.467) 0.015
  ≥ 7 2.012 (1.814–2.232) < 0.001 2.101 (1.844–2.393) < 0.001 1.713 (1.441–2.035) < 0.001
Lymph nodes ratio   < 0.001   < 0.001   < 0.001
  < 0.07 1.000   1.000   1.000  
 0.07–0.25 1.312 (1.267–1.360) < 0.001 1.375 (1.318–1.435) < 0.001 1.245 (1.168–1.327) < 0.001
 0.25–0.50 1.771 (1.704–1.842) < 0.001 1.942 (1.853–2.036) < 0.001 1.597 (1.490–1.711) < 0.001
 0.50–1.0 2.873 (2.761–2.990) < 0.001 3.302 (3.147–3.466) < 0.001 2.446 (2.279–2.625) < 0.001
Tumor site
 Left-sided vs. Right-sided 0.716 (0.698–0.734) < 0.001     
aTotal number of lymph node
  ≥ 12 vs. < 12 0.758 (0.739–0.778) < 0.001 0.692 (0.670–0.715) < 0.001 0.765 (0.733–0.798) < 0.001
bTotal number of lymph node 0.985 (0.983–0.986) < 0.001 0.980 (0.978–0.982) < 0.001 0.986 (0.983–0.988) < 0.001
cTotal number of lymph nodes
  ≥ 11 vs. < 11      0.742 (0.706–0.779) < 0.001
  1. Abbreviations: aTotal number of lymph nodes as the Categorical variable
  2. bTotal number of lymph nodes as a continuous variable
  3. cThe threshold of total number of lymph nodes as 11 in the Left-sided cohort