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Table 1 Clinicopathologic characteristics of patients

From: LYL1 gene amplification predicts poor survival of patients with uterine corpus endometrial carcinoma: analysis of the Cancer genome atlas data

Characteristics All (n = 370, %) LYL1 amplification (n = 22, %) LYL1 non-amplification (n = 348, %) P
Age, years     < 0.001
 Mean ± SD 63.1 ± 11.0 72.7 ± 8.0 62.5 ± 10.9  
Menopausea     0.393
 Yes 313 (84.6) 0 (0) 27 (7.8)  
 No 27 (7.3) 21 (95.5) 292 (83.9)
 Unknown 30 (8.1) 1 (4.5) 29 (8.3)
Diabetes     0.774
 Yes 83 (22.4) 5 (22.7) 78 (22.4)  
 No 221 (59.7) 11 (50.0) 210 (60.3)
 Unknown 66 (17.8) 6 (27.3) 60 (17.2)
Hypertension     0.420
 Yes 195 (52.7) 11 (50.0) 184 (52.9)  
 No 135 (36.5) 5 (22.7) 130 (37.4)
 Unknown 40 (10.8) 6 (27.3) 34 (9.8)
Histologic type     < 0.001
 Endometrioid 304 (82.2) 6 (27.3) 298 (85.6)  
 Serous 52 (14.1) 13 (59.1) 39 (11.2)
 Mixed 14 (3.8) 3 (13.6) 11 (3.2)
Grade     < 0.001
 1 88 (23.8) 0 (0) 88 (25.3)  
 2 106 (28.6) 1 (4.5) 105 (30.2)
 3 176 (47.6) 21 (95.5) 155 (44.5)
FIGO stage     0.003
 I 254 (68.6) 9 (40.9) 245 (70.4)  
 II 24 (6.5) 2 (9.1) 22 (6.3)
 III 72 (19.5) 9 (40.9) 63 (18.1)
 IV 17 (4.6) 2 (9.1) 15 (4.3)
 Unknown 3 (0.8) 0 (0) 3 (0.9)
TCGA type
 POLE ultra-mutated 17 (4.6) 0 (0) 17 (4.9) 0.612
 MSI hyper-mutated 65 (17.6) 0 (0) 65 (18.7) 0.019
 Low copy number 90 (24.3) 0 (0) 90 (25.9) 0.006
 High copy-number 58 (15.7) 16 (72.7) 42 (12.1) < 0.001
 Indeterminate 140 (37.8) 6 (27.3) 134 (38.5) 0.292
MSI status     < 0.001
 Stable 223 (60.2) 22 (100.0) 201 (57.8)  
 Low 19 (5.1) 0 (0) 19 (5.5)
 High 125 (33.7) 0 (0) 125 (35.9)
 Indeterminate 3 (0.8) 0 (0) 3 (0.9)
Adjuvant treatment
 Chemotherapy only 110 (29.7) 11 (50.0) 99 (28.4) 0.032
 Radiation only 55 (14.9) 2 (9.1) 53 (15.2) 0.756
 Chemotherapy + Radiation 23 (6.2) 1 (4.5) 22 (6.3) 1.000
 Hormone therapy 17 (4.6) 0 (0) 17 (4.9) 0.612
  1. Abbreviations: FIGO International Federation of Gynecology and Obstetrics, TCGA The Cancer Genome Atlas; POLE polymerase ɛ, MSI microsatellite instability, SD standard deviation
  2. aMenopause was defined as amenorrhea for 6 months or more