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Fig. 2 | BMC Cancer

Fig. 2

From: Clinically significant association of elevated expression of nuclear factor E2-related factor 2 expression with higher glucose uptake and progression of upper urinary tract cancer

Fig. 2

Representative immunohistochemistry in the primary tumor tissues for anti-Nrf2 antibody. Cancer cells showed positive reaction, but normal uroepithelium did not (a). Superficial tumors with grade 1/2 showed heterogeneous staining in nuclear and cytoplasm (b). Many of tumor cells in invasive tumors with grade 3 showed strong staining in nuclear and cytoplasm (c). The tumor cells in metastatic lymph node showed moderate to strong staining in nuclear and cytoplasm (d). In a case of invasive pT3 tumor, submucosal invasive tumor cells with grade 3 showed intense staining in nucleus and cytoplasm compared to superficial papillary tumor with grade 1/2 showing weak to moderate staining in cytoplasm with negative to weak nuclear staining (e)

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