Comparison of the seventh and eighth editions of the UICC/AJCC staging system for nasopharyngeal carcinoma: analysis of 1317 patients treated with intensity-modulated radiotherapy at two centers

Table 5 Independent prognostic survival factors for local relapse, disease failure and death in multivariate Cox regression analyses

End-point	Factor	Value	HR	95% HR
Local failure	Prevertebral muscle	0.048	1.319	1.003–1.734
Local failure	Medial pterygoid muscle	0.011	1.607	1.116–2.315
Disease failure	Gender (female vs. male)	0.012	1.539	1.100–2.154
	Prevertebral muscle	< 0.001	1.339	1.171–1.532
	Cranial nerve	< 0.001	1.675	1.291–2.171
	8th edition N category	< 0.001	1.692	1.461–1.960
Death	Gender	0.007	1.715	1.162–2.530
	Age (≤ 50 vs. > 50)	0.031	1.365	1.028–1.817
	Prevertebral muscle	0.001	1.308	1.111–1.541
	Skull base infiltration	0.011	1.582	1.113–2.248
	Cranial nerve	< 0.001	1.860	1.454–2.379
	8th edition N category	< 0.001	1.615	1.362–1.191

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