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Table 1 Classification criteria of the 7th and 8th editions of the UICC/AJCC staging system for nasopharyngeal carcinoma

From: Comparison of the seventh and eighth editions of the UICC/AJCC staging system for nasopharyngeal carcinoma: analysis of 1317 patients treated with intensity-modulated radiotherapy at two centers

  7th edition 8th edition
T category
 T0   No tumor identified, but EBV-positive cervical node involvement
 T1 Nasopharynx, oropharynx or nasal cavity Nasopharynx, oropharynx, nasal cavity without parapharyngeal involvement
 T2 Parapharyngeal extension Parapharyngeal space and/or adjacent soft tissue involvement (medial pterygoid, lateral pterygoid, prevertebral muscles)
 T3 Bony structures and/or paranasal sinuses Bony structures at skull base, cervical vertebra, pterygoid structures, and/or paranasal sinuses
 T4 Intracranial extension and/or cranial nerves, hypopharynx, orbit or infratemporal fossa/masticatory space* Intracranial extension, involvement of cranial nerves, hypopharynx, orbit, parotid gland and/or extensive soft tissue infiltration beyond lateral surface of lateral pterygoid
N category
 N0 None None
 N1 Unilateral cervical and/or unilateral or bilateral retropharyngeal node(s), ≤ 6 cm in greatest dimension, above supraclavicular fossa Unilateral cervical and/or unilateral or bilateral retropharyngeal node(s), ≤ 6 cm in greatest dimension, above caudal border of cricoid cartilage
 N2 Bilateral cervical node(s), ≤ 6 cm in greatest dimension, above supraclavicular fossa Bilateral cervical node(s), ≤ 6 cm in greatest dimension, above caudal border of cricoid cartilage
 N3 N3a > 6 cm in greatest dimension, above supraclavicular fossa Unilateral or bilateral cervical node(s), > 6 cm in greatest dimension, below caudal border of cricoid cartilage
N3b in supraclavicular fossa
Clinical stage
 I T1N0M0 T1N0M0
 II T1N1M0, T2N0-1M0 T1N1M0, T2N0-1M0
 III T1-2N2M0, T3N0-2M0 T1-2N2M0, T3N0-2M0
 IV IVA: T4N0-2M0 T4N0-2M0, T0-4N3M0
IVB: any T1-4N3M0
  1. ainfratemporal fossa/masticatory space: the superficial layer of the deep cervical fascia splits to enclose the four masticatory muscles, including the medial pterygoid (MP), lateral pterygoid (LP), temporalis and masseter muscles, to enclose this space