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Table 1 The cell lines investigated

From: Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation

Cell line Origin HER2 status Reported sensitivity to T-DM1
SKBR-3 Human breast cancer Positive Sensitive (IC50 0.005 μg/mL) [1, 6]
EFM-192A Human breast cancer Positive Sensitive (IC50 0.426 μg/mL) [6]
SNU-216 Human gastric cancer Positive Insensitive (IC50 > 10 μg/mL) [17]
MCF-7 Human breast cancer Negative Insensitive (IC50 > 10 μg/mL) [6]
  1. IC50, half-maximal inhibitory concentration