Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation

Table 1 The cell lines investigated

Cell line	Origin	HER2 status	Reported sensitivity to T-DM1
SKBR-3	Human breast cancer	Positive	Sensitive (IC₅₀ 0.005 μg/mL) [1, 6]
EFM-192A	Human breast cancer	Positive	Sensitive (IC₅₀ 0.426 μg/mL) [6]
SNU-216	Human gastric cancer	Positive	Insensitive (IC₅₀ > 10 μg/mL) [17]
MCF-7	Human breast cancer	Negative	Insensitive (IC₅₀ > 10 μg/mL) [6]

ISSN: 1471-2407