Fig. 5From: HPV-16 E7 expression up-regulates phospholipase D activity and promotes rapamycin resistance in a pRB-dependent mannerA proposed model for HPV-16 E7 induced resistance to rapamycin and PLD activation. In HPV-16 E7 expressing cells, high intracellular PA levels, generated by increased PLD activity, competes with rapamycin for mTOR binding leading to an increase in cell proliferationBack to article page