Fig. 5
From: Reduction of MHC-I expression limits T-lymphocyte-mediated killing of Cancer-initiating cells
CICs treated with IFN-γ become less tumorigenic. Mice (n = 4 for 120,000 group and n = 8 for remaining groups) were subcutaneously injected with 120,000, 40,000, 10,000, or 5000 cells from TC-1 non-CICs (closed circles), CICs (open circles), non-CICs treated with IFN-γ (closed triangles), or CICs treated with IFN-γ (open triangles). a Tumor-free survival for the 10,000 cell group was assessed and by day 66 was found to be significantly shorter for CICs (*P = 0.027). b Confidence interval plot of an extreme limiting dilution analysis to assess CIC frequency per number of cells is shown. Untreated CICs are more tumorigenic than the other three groups (****P < 0.001, ***P = 0.00135, **P = 0.00549)